Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 16/20 | 0.55 |
| ▸ | HRH1 | P35367 | 14/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.40 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.39 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL180455 | 0.92 | HRH1 (0.59) | CCR3HRH1KCNH2ACHEHTR4 | |
| SCHEMBL4161536 | 0.83 | CCR3 (0.58) | CCR3HRH1KCNH2 | |
| SCHEMBL1928032 | 0.83 | HRH1 (0.44) | CCR3HRH1KCNH2 | |
| SCHEMBL5192558 | 0.82 | CCR3 (0.64) | CCR3HRH1KCNH2 | |
| SCHEMBL5414677 | 0.81 | CCR3 (0.54) | CCR3HRH1KCNH2 | |
| SCHEMBL4967049 | 0.81 | HRH1 (0.59) | CCR3HRH1KCNH2 | |
| SCHEMBL4969392 | 0.81 | HRH1 (0.56) | CCR3HRH1KCNH2 | |
| SCHEMBL180214 | 0.81 | HRH1 (0.60) | CCR3HRH1KCNH2 | |
| SCHEMBL5193030 | 0.81 | HRH1 (0.55) | CCR3HRH1KCNH2 | |
| SCHEMBL5189845 | 0.80 | HRH1 (0.60) | CCR3HRH1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1625114-B1 | Piperidine derivatives for the the treatment of chemokine or H1 mediated diseases | ASTRAZENECA AB (SE) | 2008-08-27 | — | — | EP | disclosed |
| EP-1816123-A1 | Intermediates for the production of pharmaceutically active compounds | AstraZeneca AB (SE) | 2007-08-08 | — | — | EP | disclosed |
| EP-1546130-B1 | PIPERIDINE DERIVATIVES FOR USE IN THE TREATMENT OF CHEMOKINE MEDIATED DISEASE STATES | ASTRAZENECA AB (SE) | 2007-08-01 | — | — | EP | disclosed |