Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 18/20 | 0.67 |
| ▸ | CCR3 | P51677 | 18/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 13/20 | 0.67 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.48 |
| ▸ | LIPC | P11150 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4969238 | 0.90 | HRH1 (0.56) | HRH1CCR3KCNH2 | |
| SCHEMBL4967181 | 0.90 | HRH1 (0.54) | HRH1CCR3KCNH2LIPGLIPC | |
| SCHEMBL4967162 | 0.88 | HRH1 (0.85) | HRH1CCR3KCNH2 | |
| SCHEMBL4968585 | 0.85 | HRH1 (0.57) | HRH1CCR3KCNH2LIPGLIPC | |
| SCHEMBL4969400 | 0.84 | HRH1 (0.65) | HRH1CCR3KCNH2 | |
| SCHEMBL4968203 | 0.83 | HRH1 (0.63) | HRH1CCR3KCNH2 | |
| SCHEMBL4967810 | 0.81 | HRH1 (0.46) | HRH1CCR3KCNH2 | |
| SCHEMBL4970161 | 0.80 | HRH1 (1.00) | HRH1CCR3KCNH2 | |
| SCHEMBL4967140 | 0.80 | HRH1 (0.69) | HRH1CCR3KCNH2 | |
| SCHEMBL5192764 | 0.80 | HRH1 (0.78) | HRH1CCR3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1625114-B1 | Piperidine derivatives for the the treatment of chemokine or H1 mediated diseases | ASTRAZENECA AB (SE) | 2008-08-27 | — | — | EP | disclosed |