Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.63 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.51 |
| ▸ | PTGER2 | P43116 | 4/20 | 0.51 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.51 |
| ▸ | PTGER3 | P43115 | 3/20 | 0.51 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.50 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1270178 | 1.00 | HDAC8 (0.63) | HDAC8PTGER4PTGER2PTGER1PTGER3 | |
| SCHEMBL9199949 | 0.88 | HDAC8 (0.65) | HDAC8PTGER4PTGER2PTGER1PTGER3 | |
| SCHEMBL3409444 | 0.87 | PTGER4 (0.67) | HDAC8PTGER4PTGER2PTGER1PTGER3 | |
| SCHEMBL3409441 | 0.87 | PTGER4 (0.67) | HDAC8PTGER4PTGER2PTGER1PTGER3 | |
| SCHEMBL7770104 | 0.84 | PTGER4 (0.70) | HDAC8PTGER4PTGER2PTGER1PTGER3 | |
| SCHEMBL19651747 | 0.84 | PTGER4 (0.70) | HDAC8PTGER4PTGER2PTGER1PTGER3 | |
| SCHEMBL18559977 | 0.81 | HDAC8 (0.69) | HDAC8BACE1AKR1B10AKR1B1KDM4E | |
| SCHEMBL31690782 | 0.78 | HDAC8 (0.54) | HDAC8PTGER4PTGER2PTGER1PTGER3 | |
| SCHEMBL1269190 | 0.78 | KDM4E (0.57) | KDM4EALDH1A1HPGDHTTAPP | |
| SCHEMBL1270179 | 0.78 | HDAC8 (0.45) | HDAC8PTGER4PTGER2PTGER1PTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781274-B1 | NOVEL BIAROMATIC COMPOUNDS WHICH ACTIVATE RECEPTORS OF PPAR TYPE AND THEIR USE IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS | GALDERMA RES & DEV (FR) | 2008-11-05 | — | — | EP | disclosed |
| US-20070207175-A1 | Biaromatic compound activators of PPARgamma receptors and cosmetic/pharmaceutical compositions comprised thereof | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2007-09-06 | — | — | US | disclosed |
| CN-101014328-A | Novel biaromatic compounds which activate receptors of PPAR type and their use in cosmetic or pharmaceutical compositions | GALDERMA RES & DEV (FR) | 2007-08-08 | — | — | CN | disclosed |
| EP-1781274-A1 | NOVEL BIAROMATIC COMPOUNDS WHICH ACTIVATE RECEPTORS OF PPAR TYPE AND THEIR USE IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS | Galderma Research & Development, S.N.C. (FR) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006018325-A1 | NOVEL BIAROMATIC COMPOUNDS WHICH ACTIVATE RECEPTORS OF PPAR TYPE AND THEIR USE IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS | GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) | 2006-02-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070207175-A1 | Biaromatic compound activators of PPARgamma receptors and cosmetic/pharmaceutical compositions comprised thereof | PPARG, PPARA, PPARD | HDAC8 415/4885PTGER4 424/4885PTGER2 405/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.