Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 1/20 | 0.62 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.38 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL400165 | 0.91 | SMO (0.75) | SMOP4HTMKMT2AMEN1HIF1A | |
| SCHEMBL15865032 | 0.86 | SMO (0.82) | SMOP4HTMCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL4973693 | 0.86 | MAPK7 (0.50) | SMOP4HTMLMNABRAFHIF1A | |
| SCHEMBL4973956 | 0.86 | SMO (0.47) | SMOP4HTMKMT2AMEN1MAPT | |
| SCHEMBL4971496 | 0.84 | SMN1; SMN2 (0.47) | SMOP4HTMKMT2AMEN1MAPT | |
| SCHEMBL14530571 | 0.81 | SMO (0.62) | SMOP4HTMKMT2AMEN1MAPT | |
| SCHEMBL4969513 | 0.78 | SMO (0.73) | SMOKMT2AMEN1MAPTLMNA | |
| SCHEMBL4968510 | 0.78 | MAPK7 (0.52) | MAPTLMNABRAFHIF1AEPAS1 | |
| SCHEMBL4972109 | 0.78 | SMO (0.75) | SMOMAPTLMNAHDAC1ALDH1A1 | |
| SCHEMBL4970168 | 0.78 | SMO (0.72) | SMOCHRNB4CHRNA3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957461-A1 | BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING | Genentech, Inc. (US) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007059157-A1 | BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING | GENENTECH, INC. (US) | 2007-05-24 | — | — | WO | disclosed |