Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phenolphthalein. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.82 |
| ▸ | MEN1 | O00255 | 3/20 | 0.82 |
| ▸ | LMNA | P02545 | 3/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.82 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.82 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.82 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.82 |
| ▸ | TYMS | P04818 | 2/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.82 |
| ▸ | ESR1 | P03372 | 1/20 | 0.82 |
| ▸ | TP53 | P04637 | 1/20 | 0.82 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.82 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.82 |
| ▸ | TSHR | P16473 | 1/20 | 0.82 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.82 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.82 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.61 |
| ▸ | CFTR | P13569 | 1/20 | 0.61 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenolphthalein SCHEMBL7926066 | 0.91 | MAPT (0.88) | MAPTMEN1LMNAKMT2ATDP1 | |
| Phenolphthalein SCHEMBL2546185 | 0.91 | MAPT (0.88) | MAPTMEN1LMNAKMT2ATDP1 | |
| Phenolphthalein SCHEMBL28196770 | 0.91 | MAPT (0.93) | MAPTMEN1LMNAKMT2ATDP1 | |
| Phenolphthalein SCHEMBL27670 | 0.91 | MAPT (1.00) | MAPTMEN1LMNAKMT2ATDP1 | |
| Phenolphthalein SCHEMBL6139696 | 0.91 | MAPT (1.00) | MAPTMEN1LMNAKMT2ATDP1 | |
| Phenolphthalein SCHEMBL29362413 | 0.91 | MAPT (1.00) | MAPTMEN1LMNAKMT2ATDP1 | |
| Phenolphthalein SCHEMBL23929043 | 0.89 | MAPT (0.97) | MAPTMEN1LMNAKMT2ATDP1 | |
| Phenolphthalein SCHEMBL3420446 | 0.89 | MAPT (0.97) | MAPTMEN1LMNAKMT2ATDP1 | |
| Phenolphthalein SCHEMBL4749522 | 0.89 | MAPT (0.97) | MAPTMEN1LMNAKMT2ATDP1 | |
| Phenolphthalein SCHEMBL7479687 | 0.89 | MAPT (0.97) | MAPTMEN1LMNAKMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694567-B1 | Method for treating a fabric | UNILEVER PLC (GB) | 2008-08-20 | — | — | EP | disclosed |
| EP-1697219-B1 | FOAM AND/OR MIST DISPENSER | UNILEVER PLC (GB) | 2007-05-30 | — | — | EP | disclosed |
| EP-1697219-A1 | FOAM AND/OR MIST DISPENSER | UNILEVER PLC (GB) | 2006-09-06 | — | — | EP | disclosed |
| EP-1694567-A1 | FOAM AND/OR MIST DISPENSER | Unilever Plc (GB) | 2006-08-30 | — | — | EP | disclosed |
| WO-2005058712-A1 | FOAM AND/OR MIST DISPENSER | UNILEVER PLC (GB) | 2005-06-30 | — | — | WO | disclosed |
| WO-2005058711-A1 | FOAM AND/OR MIST DISPENSER | UNILEVER PLC (GB) | 2005-06-30 | — | — | WO | disclosed |