Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2809228 | 0.82 | NPC1 (0.41) | KMT2ANPC1RAB9ATLR8CYP1A2 | |
| SCHEMBL4964660 | 0.81 | TLR8 (0.61) | TLR8TLR7 | |
| SCHEMBL2807423 | 0.80 | CYP1A2 (0.61) | KMT2ANPC1RAB9ACYP1A2CYP2C19 | |
| SCHEMBL2806860 | 0.78 | TLR8 (0.37) | KMT2ANPC1ALOX5EPHX2RAB9A | |
| SCHEMBL1528140 | 0.78 | SMN1; SMN2 (0.43) | KMT2ANPC1RAB9ATLR8CYP1A2 | |
| SCHEMBL13128110 | 0.78 | NPC1 (0.40) | KMT2ANPC1RAB9ATLR8CYP1A2 | |
| SCHEMBL2806864 | 0.77 | TLR8 (0.44) | KMT2ANPC1ALOX5EPHX2RAB9A | |
| SCHEMBL1528127 | 0.76 | TLR8 (0.41) | KMT2ANPC1RAB9ATLR8CYP1A2 | |
| Hydrochloric Acid SCHEMBL31461700 | 0.74 | UBE2T (0.51) | TLR8TLR7KDM4E | |
| Hydrochloric Acid SCHEMBL31461696 | 0.74 | UBE2T (0.51) | TLR8TLR7KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1877056-A2 | OXIME AND HYDROXYLAMINE SUBSTITUTED THIAZOLOÝ4,5-C¨RING COMPOUNDS AND METHODS | Coley Pharmaceutical Group, Inc. (US) | 2008-01-16 | — | — | EP | disclosed |
| WO-2007120121-A2 | OXIME AND HYDROXYLAMINE SUBSTITUTED THIAZOLO[4,5-C] RING COMPOUNDS AND METHODS | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2007-10-25 | — | — | WO | disclosed |