Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10615884 | 0.77 | HDAC3 (0.47) | HDAC3LMNA | |
| SCHEMBL14637926 | 0.76 | HDAC3 (0.69) | HDAC3TSHRHTTCHRM3DRD2 | |
| SCHEMBL28774659 | 0.74 | HDAC3 (0.52) | HDAC3LMNATSHRHTTCHRM3 | |
| SCHEMBL1128087 | 0.74 | HDAC3 (0.52) | HDAC3LMNATSHRHTTCHRM3 | |
| SCHEMBL5141015 | 0.74 | HDAC3 (0.56) | HDAC3LMNATSHRHTTACHE | |
| SCHEMBL29767826 | 0.74 | HDAC3 (0.52) | HDAC3LMNATSHRHTTCHRM3 | |
| Bromide SCHEMBL6024516 | 0.73 | HDAC3 (0.51) | HDAC3LMNATSHRHTTCHRM3 | |
| Iodide SCHEMBL10482578 | 0.73 | HDAC3 (0.51) | HDAC3LMNATSHRHTTCHRM3 | |
| SCHEMBL10868161 | 0.72 | HDAC3 (0.60) | HDAC3TSHRDRD2SIGMAR1 | |
| SCHEMBL1127857 | 0.72 | HDAC3 (0.57) | HDAC3NAMPTSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8198298-B2 | Pyrrolo[2,3-b]pyridine derivatives active as kinase inhibitors | PFIZER ITALIA S.R.L. (IT) | 2012-06-12 | — | — | US | disclosed |
| US-8106069-B2 | Pyrrolo[2,3-b]pyridine derivatives active as kinase inhibitors and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2012-01-31 | — | — | US | disclosed |
| US-20110136857-A1 | PYRROLE[2,3-B]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS | PFIZER ITALIA S.R.L. (IT) | 2011-06-09 | — | — | US | disclosed |
| US-7888508-B2 | 3-(carboxy or carbamoyl)-5-amino-1H-pyrrolo(2,3-b)pyridines; cancer, Alzheimer's disease, viral infections, autoimmune diseases and neurodegenerative disorders; chemical libraries of these compounds | PFIZER ITALIA S.R.L. (IT) | 2011-02-15 | — | — | US | disclosed |
| US-20100210476-A1 | Pyrrolo[2,3-b]Pyridine Derivatives Active as Kinase Inhibitors and Pharmaceutical Compositions Comprising Them | PFIZER ITALIA S.R.L. (IT) | 2010-08-19 | — | — | US | disclosed |
| US-7728140-B2 | Pyrrolo[2,3-b]pyridine derivatives active as kinase inhibitors and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2010-06-01 | — | — | US | disclosed |
| EP-1701956-B1 | PYRROLO[2,3-B]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PFIZER ITALIA SRL (IT) | 2010-02-24 | — | — | EP | disclosed |
| EP-1704147-B1 | PYRROLO[2,3-b] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION COMPRISING THEM | PFIZER ITALIA SRL (IT) | 2009-11-04 | — | — | EP | disclosed |
| EP-1704147-A1 | PYRROLO[2,3-b] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION COMPRISING THEM | Pfizer Italia S.r.l. (IT) | 2006-09-27 | — | — | EP | disclosed |
| EP-1701956-A1 | PYRROLO[2,3-B]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pfizer Italia S.r.l. (IT) | 2006-09-20 | — | — | EP | disclosed |
| US-20050256151-A1 | Pyrrolo[2,3-b]pyridine derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PHARMACIA ITALIA S.P.A. (IT) | 2005-11-17 | — | — | US | disclosed |
| US-20050209269-A1 | Pyrrolo[2,3-b]pyridine derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PHARMACIA ITALIA S.P.A. (IT) | 2005-09-22 | — | — | US | disclosed |
| WO-2005063747-A1 | PYRROLO[2,3-b] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION COMPRISING THEM | PFIZER ITALIA S.R.L. (IT) | 2005-07-14 | — | — | WO | disclosed |
| WO-2005063746-A1 | PYRROLO[2,3-b]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PFIZER ITALIA S.R.L. (IT) | 2005-07-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100210476-A1 | Pyrrolo[2,3-b]Pyridine Derivatives Active as Kinase Inhibitors and Pharmaceutical Compositions Comprising Them | MAP3K6, MAP3K3, MAP3K1 | HDAC3 2493/4885NPSR1 2389/4885LMNA 4001/4885 |
| US-20050256151-A1 | Pyrrolo[2,3-b]pyridine derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | MAP3K6, MAP3K3, MAP3K1 | HDAC3 2755/4885NPSR1 2000/4885LMNA 3842/4885 |
| US-20110136857-A1 | PYRROLE[2,3-B]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS | MAP3K6, MAP3K3, MAP3K15 | HDAC3 2979/4885NPSR1 2193/4885LMNA 4426/4885 |
| US-20050209269-A1 | Pyrrolo[2,3-b]pyridine derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | MAP3K6, MAP3K3, MAP3K1 | HDAC3 2755/4885NPSR1 2000/4885LMNA 3842/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.