Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 12/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4964809 | 0.88 | KDM4E (0.40) | HDAC6HDAC1HDAC8HDAC2HDAC3 | |
| SCHEMBL14533493 | 0.84 | HDAC6 (0.47) | HDAC6HDAC1HDAC8HDAC2HDAC3 | |
| SCHEMBL4803201 | 0.83 | HDAC3 (0.48) | HDAC6HDAC1HDAC8HDAC2HDAC3 | |
| SCHEMBL4801391 | 0.82 | HDAC6 (0.46) | HDAC6HDAC1HDAC8HDAC2HDAC3 | |
| SCHEMBL4801027 | 0.79 | HDAC1 (0.45) | HDAC6HDAC1HDAC8HDAC2HDAC3 | |
| SCHEMBL4966198 | 0.79 | MAOB (0.39) | MAOBCNR2CNR1 | |
| SCHEMBL4807256 | 0.78 | HDAC1 (0.44) | HDAC6HDAC1HDAC8HDAC2HDAC3 | |
| SCHEMBL3495549 | 0.76 | HDAC6 (0.43) | HDAC6HDAC1HDAC8HDAC2HDAC3 | |
| SCHEMBL3495556 | 0.76 | HDAC6 (0.43) | HDAC6HDAC1HDAC8HDAC2HDAC3 | |
| SCHEMBL3493411 | 0.75 | MAPT (0.39) | MAOBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934220-A1 | INHIBITORS OF THE HIV INTEGRASE ENZYME | Pfizer Products Incorporated (US) | 2008-06-25 | — | — | EP | disclosed |
| EP-1817329-A1 | GEM DIFLUORINATED C-GLYCOPEPTIDES, THEIR PREPARATION AND THEIR USE FOR THE PRESERVATION OF BIOLOGICAL MATERIALS AND/OR IN CRYOSURGERY | Institut National des Sciences Appliquees de Rouen (INSA) (FR) | 2007-08-15 | — | — | EP | disclosed |
| US-20070099915-A1 | INHIBITORS OF THE HIV INTEGRASE ENZYME | PFIZER INC. | 2007-05-03 | — | — | US | disclosed |
| US-20070099915-A1 | INHIBITORS OF THE HIV INTEGRASE ENZYME | PFIZER INC. | 2007-05-03 | — | — | US | disclosed |
| WO-2007042883-A1 | INHIBITORS OF THE HIV INTEGRASE ENZYME | PFIZER PRODUCTS INC. (US) | 2007-04-19 | — | — | WO | disclosed |
| WO-2006059227-A1 | GEM DIFLUORINATED C-GLYCOPEPTIDES, THEIR PREPARATION AND THEIR USE FOR THE PRESERVATION OF BIOLOGICAL MATERIALS AND/OR IN CRYOSURGERY | INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE ROUEN (INSA) (FR) | 2006-06-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099915-A1 | INHIBITORS OF THE HIV INTEGRASE ENZYME | IMPDH1, INTS9, TYMP | HDAC6 1926/4885HDAC1 626/4885HDAC8 2180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.