Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17407919 | 0.84 | PDE10A (0.43) | KMT2AMEN1PDE10ARAF1BRAF | |
| SCHEMBL2815435 | 0.82 | PIK3CD (0.43) | SMN1; SMN2PIK3CAPIK3R1 | |
| SCHEMBL2816228 | 0.82 | PIK3CD (0.43) | SMN1; SMN2PIK3CAPIK3R1 | |
| SCHEMBL2815436 | 0.82 | PIK3CD (0.43) | SMN1; SMN2PIK3CAPIK3R1 | |
| SCHEMBL4975886 | 0.81 | EGLN1 (0.37) | KMT2AMEN1PDE10ARAF1BRAF | |
| SCHEMBL2815691 | 0.80 | PDE10A (0.46) | KMT2AMEN1PDE10ARAF1BRAF | |
| SCHEMBL2813072 | 0.78 | PIK3CD (0.48) | PIK3CAPIK3R1 | |
| SCHEMBL2813469 | 0.78 | PIK3CD (0.48) | PIK3CAPIK3R1 | |
| SCHEMBL2813070 | 0.78 | PIK3CD (0.48) | PIK3CAPIK3R1 | |
| SCHEMBL2815645 | 0.77 | JAK3 (0.44) | KMT2AMEN1PDE10ARAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984350-A1 | PYRIMIDINE DERIVATIVES USED AS PI-3 KINASE INHIBITORS | Novartis AG (CH) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007084786-A1 | PYRIMIDINE DERIVATIVES USED AS PI-3 KINASE INHIBITORS | NOVARTIS AG (CH) | 2007-07-26 | — | — | WO | disclosed |