Cilostamide

Cilostamide

SCHEMBL49742

CN(C(=O)CCCOc1ccc2[nH]c(=O)ccc2c1)C1CCCCC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE3B Q13370 20/20 1.00
PDE3A Q14432 20/20 1.00
KDM4E B2RXH2 1/20 1.00
MEN1 O00255 1/20 1.00
PDE5A O76074 1/20 1.00
ALDH1A1 P00352 1/20 1.00
CYP1A2 P05177 1/20 1.00
CYP3A4 P08684 1/20 1.00
HPGD P15428 1/20 1.00
TSHR P16473 1/20 1.00
PTAFR P25105 1/20 1.00
CYP2C19 P33261 1/20 1.00
BLM P54132 1/20 1.00
PDE1A P54750 1/20 1.00
PDE1B Q01064 1/20 1.00
PMP22 Q01453 1/20 1.00
KMT2A Q03164 1/20 1.00
PDE1C Q14123 1/20 1.00
HSD17B10 Q99714 1/20 1.00
P2RY12 Q9H244 11/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11317158 1.00 PDE3B (1.00) PDE3BPDE3AKDM4EMEN1PDE5A
Cilostamide SCHEMBL29491047 1.00 PDE3B (1.00) PDE3BPDE3AKDM4EMEN1PDE5A
Cilostamide SCHEMBL11310308 0.97 PDE3B (0.94) PDE3BPDE3AKDM4EMEN1PDE5A
SCHEMBL11313093 0.96 PDE3B (0.92) PDE3BPDE3AKDM4EMEN1PDE5A
SCHEMBL11323306 0.94 PDE3B (0.88) PDE3BPDE3AKDM4EMEN1PDE5A
SCHEMBL11310303 0.92 PDE3B (0.85) PDE3BPDE3AKDM4EMEN1PDE5A
SCHEMBL11342927 0.91 PDE3B (0.83) PDE3BPDE3AKDM4EMEN1PDE5A
SCHEMBL11405231 0.91 PDE3B (0.83) PDE3BPDE3AKDM4EMEN1PDE5A
SCHEMBL11313013 0.91 PDE3B (0.83) PDE3BPDE3AKDM4EMEN1PDE5A
SCHEMBL11322940 0.90 PDE3B (0.82) PDE3BPDE3AKDM4EMEN1PDE5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3422 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240165029-A1 ASSISTED LOADING OF HYDROPHOBIC MOLECULES INTO LIPOSOMES UNIVERSITY OF CONNECTICUT 2024-05-23 US claimed
US-11903992-B2 Composition comprising lidocaine, l-carnosine and dexpanthenol CELLIX BIO PRIVATE LIMITED (IN) 2024-02-20 US claimed
WO-2023196821-A2 TARGETING NEUROPOD CELL GUCY2C TO CONTROL VISCERAL PAIN AND APPETITE THOMAS JEFFERSON UNIVERSITY (US) 2023-10-12 WO claimed
US-20220313719-A1 METHODS OF TREATING DISEASES ASSOCIATED WITH CHANGES IN PLATELET COUNTS USING PROTEIN KINASE A ACTIVATOR AND INHIBITOR SOOCHOW UNIVERSITY (CN) 2022-10-06 US claimed
WO-2022192275-A1 ASSISTED LOADING OF HYDROPHOBIC MOLECULES INTO LIPOSOMES UNIVERSITY OF CONNECTICUT (US) 2022-09-15 WO claimed
WO-2022190030-A1 A TOPICAL FORMULATION FOR THE TREATMENT OF SKIN DISEASES AVACA PHARMA PRIVATE LIMITED (IN) 2022-09-15 WO claimed
WO-2022157587-A1 A COMPOSITION COMPRISING LIDOCAINE, L-CARNOSINE AND DEXPANTHENOL CELLIX BIO PRIVATE LIMITED (IN) 2022-07-28 WO claimed
US-20220233629-A1 COMPOSITION COMPRISING LIDOCAINE, L-CARNOSINE AND DEXPANTHENOL CELLIX BIO PRIVATE LIMITED (IN) 2022-07-28 US claimed
US-20220184052-A1 COMPOSITION COMPRISING FEXOFENADINE CELLIX BIO PRIVATE LIMITED (IN) 2022-06-16 US claimed
WO-2022123511-A1 A COMPOSITION COMPRISING FEXOFENADINE CELLIX BIO PRIVATE LIMITED (IN) 2022-06-16 WO claimed
US-6110471-A ADMINISTERING PHOSPHODIESTERASE FOR INHIBITION OF THE CYCLES THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2000-08-29 US claimed
EP-1028690-A2 LUTEINISING HORMONE ANTAGONISTS USEFUL FOR TREATMENT OF ESTROGEN DEFICIENCIES, OR AS A CONTRACEPTIVE NOVO NORDISK A/S (DK) 2000-08-23 EP claimed
WO-2000012076-A9 NITROSATED AND NITROSYLATED PHOSPHODIESTERASE INHIBITORS, COMPOSITIONS AND METHODS OF USE NITROMED INC (US) 2000-08-17 WO claimed
EP-1012188-A1 COMPOSITION FOR TREATING DIABETES MELLITUS AND OBESITY FORSSMANN, Wolf-Georg, Prof. Dr. (DE) 2000-06-28 EP claimed
WO-2000012076-A1 NITROSATED AND NITROSYLATED PHOSPHODIESTERASE INHIBITORS, COMPOSITIONS AND METHODS OF USE NITROMED, INC. (US) 2000-03-09 WO claimed
EP-0961616-A1 NON-HORMONAL METHOD OF CONTRACEPTION THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 1999-12-08 EP claimed
WO-1999020223-A2 LUTEINISING HORMONE ANTAGONISTS USEFUL FOR TREATMENT OF ESTROGEN DEFICIENCIES, OR AS A CONTRACEPTIVE NOVO NORDISK A/S (DK) 1999-04-29 WO claimed
WO-1999014239-A1 COMPOSITION FOR TREATING DIABETES MELLITUS AND OBESITY FORSSMANN WOLF GEORG (DE) 1999-03-25 WO claimed
WO-1998010765-A1 NON-HORMONAL METHOD OF CONTRACEPTION THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 1998-03-19 WO claimed
US-4298739-A ANTICOAGULANTS, ANTIINFLAMMATORY, ANTIULCER, VASODILATOR, PHOSPHODIESTERASE INHIBITORS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1981-11-03 US claimed