Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 20/20 | 1.00 |
| ▸ | S1PR3 | Q99500 | 14/20 | 1.00 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4279459 | 0.81 | S1PR1 (0.69) | S1PR1S1PR3S1PR5 | |
| SCHEMBL1857324 | 0.80 | S1PR1 (0.67) | S1PR1S1PR3S1PR5 | |
| SCHEMBL2747674 | 0.78 | S1PR1 (0.63) | S1PR1S1PR3S1PR5 | |
| SCHEMBL4275506 | 0.77 | S1PR1 (0.80) | S1PR1S1PR3S1PR5 | |
| SCHEMBL1862109 | 0.76 | S1PR1 (0.76) | S1PR1S1PR3S1PR5 | |
| SCHEMBL4276052 | 0.76 | S1PR1 (0.77) | S1PR1S1PR3S1PR5 | |
| SCHEMBL4274575 | 0.75 | S1PR1 (0.71) | S1PR1S1PR3S1PR5 | |
| SCHEMBL4265671 | 0.75 | S1PR1 (0.84) | S1PR1S1PR3S1PR5 | |
| SCHEMBL5510818 | 0.75 | S1PR1 (0.73) | S1PR1S1PR3S1PR5 | |
| SCHEMBL4267246 | 0.74 | S1PR1 (0.86) | S1PR1S1PR3S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863474-B1 | NOVEL THIOPHENE DERIVATIVES AS SPHINGOSINE-1-PHOSPHATE-1 RECEPTOR AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2008-11-12 | — | — | EP | disclosed |