Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NEK1 | Q96PY6 | 12/20 | 0.71 |
| ▸ | IKBKB | O14920 | 8/20 | 0.68 |
| ▸ | CHUK | O15111 | 8/20 | 0.68 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.68 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | PAK4 | O96013 | 1/20 | 0.53 |
| ▸ | CSF1R | P07333 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
| ▸ | IGF1R | P08069 | 1/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.53 |
| ▸ | PRKACA | P17612 | 1/20 | 0.53 |
| ▸ | FLT1 | P17948 | 1/20 | 0.53 |
| ▸ | LTK | P29376 | 1/20 | 0.53 |
| ▸ | GRK5 | P34947 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30009778 | 0.82 | IKBKB (0.69) | NEK1IKBKBCHUKROCK1DAPK3 | |
| SCHEMBL30010048 | 0.78 | IKBKB (0.73) | NEK1IKBKBCHUKROCK1 | |
| SCHEMBL30008749 | 0.78 | IKBKB (0.69) | NEK1IKBKBCHUKROCK1DAPK3 | |
| SCHEMBL30009525 | 0.77 | IKBKB (0.76) | NEK1IKBKBCHUKROCK1DAPK3 | |
| SCHEMBL30008721 | 0.76 | IKBKB (0.70) | NEK1IKBKBCHUKROCK1DAPK3 | |
| SCHEMBL30009167 | 0.76 | IKBKB (0.66) | NEK1IKBKBCHUKROCK1DAPK3 | |
| SCHEMBL30009321 | 0.76 | IKBKB (0.66) | NEK1IKBKBCHUKROCK1PIK3C3 | |
| SCHEMBL30009843 | 0.76 | IKBKB (0.70) | NEK1IKBKBCHUKROCK1PIK3C3 | |
| SCHEMBL30009257 | 0.76 | IKBKB (0.66) | NEK1IKBKBCHUKROCK1DYRK1A | |
| SCHEMBL30009376 | 0.76 | IKBKB (0.70) | NEK1IKBKBCHUKROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962851-A2 | COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007076320-A2 | COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |