Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.67 |
| ▸ | BACE2 | Q9Y5Z0 | 19/20 | 0.67 |
| ▸ | CTSD | P07339 | 18/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3577330 | 0.86 | BACE1 (0.71) | BACE1BACE2CTSD | |
| SCHEMBL3575742 | 0.86 | BACE1 (0.71) | BACE1BACE2CTSD | |
| SCHEMBL3571501 | 0.86 | BACE1 (0.73) | BACE1BACE2CTSD | |
| SCHEMBL3578398 | 0.84 | BACE1 (0.68) | BACE1BACE2CTSD | |
| SCHEMBL4527892 | 0.80 | BACE1 (0.80) | BACE1BACE2CTSD | |
| SCHEMBL4784497 | 0.79 | BACE1 (0.79) | BACE1BACE2CTSD | |
| SCHEMBL4783931 | 0.79 | BACE1 (0.82) | BACE1BACE2CTSD | |
| SCHEMBL22025976 | 0.78 | BACE1 (0.78) | BACE1BACE2CTSD | |
| SCHEMBL3577035 | 0.78 | BACE1 (1.00) | BACE1BACE2CTSD | |
| SCHEMBL25916160 | 0.78 | BACE1 (1.00) | BACE1BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896454-A1 | AMlNO-5-(5-MEMBERED)HETEROARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR -SECRETASE MODULATION | Wyeth a Corporation of the State of Delaware (US) | 2008-03-12 | — | — | EP | claimed |
| WO-2007005366-A1 | AMlNO-5-(5-MEMBERED)HETEROARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR β-SECRETASE MODULATION | WYETH (US) | 2007-01-11 | — | — | WO | claimed |