Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CFD | P00746 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GPR183 | P32249 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4976525 | 1.00 | HSP90AB1 (0.47) | HSP90AB1ALDH1A1LMNATP53RAB9A | |
| SCHEMBL14346864 | 0.92 | HSP90AB1 (0.42) | HSP90AB1RAB9ANPC1L3MBTL1GAA | |
| SCHEMBL4976979 | 0.91 | HSP90AB1 (0.41) | HSP90AB1ALDH1A1LMNATP53RAB9A | |
| SCHEMBL4976971 | 0.91 | HSP90AB1 (0.41) | HSP90AB1ALDH1A1LMNATP53RAB9A | |
| SCHEMBL4974626 | 0.91 | MAPT (0.52) | HSP90AB1LMNARAB9ANPC1MEN1 | |
| SCHEMBL4980014 | 0.91 | MAPT (0.46) | HSP90AB1ALDH1A1LMNATP53RAB9A | |
| SCHEMBL4974630 | 0.91 | MAPT (0.52) | HSP90AB1LMNARAB9ANPC1MEN1 | |
| SCHEMBL4980006 | 0.91 | MAPT (0.46) | HSP90AB1ALDH1A1LMNATP53RAB9A | |
| SCHEMBL4980178 | 0.91 | MEN1 (0.44) | HSP90AB1LMNARAB9ANPC1MEN1 | |
| SCHEMBL4980193 | 0.91 | MEN1 (0.44) | HSP90AB1LMNARAB9ANPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | NEUROGEN CORPORATION | 2008-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051387-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES | HRH3, HRH4, HRH2 | HSP90AB1 2652/4885ALDH1A1 1142/4885LMNA 4534/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.