Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.48 |
| ▸ | IGF1R | P08069 | 4/20 | 0.48 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.48 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 2/20 | 0.41 |
| ▸ | AKT1 | P31749 | 4/20 | 0.40 |
| ▸ | AKT2 | P31751 | 4/20 | 0.40 |
| ▸ | PI4KA | P42356 | 1/20 | 0.40 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.40 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
| ▸ | HCK | P08631 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5817230 | 0.82 | LCK (0.51) | EGFRERBB2IGF1RERBB3ERBB4 | |
| SCHEMBL2960099 | 0.80 | SRC (0.55) | EGFRERBB2IGF1RERBB3ERBB4 | |
| SCHEMBL20744975 | 0.77 | EGFR (0.55) | EGFRSIGMAR1BTKAKT1AKT2 | |
| SCHEMBL30041613 | 0.77 | EGFR (0.55) | EGFRSIGMAR1BTKAKT1AKT2 | |
| Acetic Acid SCHEMBL6433943 | 0.77 | LCK (0.52) | EGFRERBB2IGF1RERBB3ERBB4 | |
| SCHEMBL30455250 | 0.76 | RET (0.49) | EGFRERBB2IGF1RERBB3ERBB4 | |
| SCHEMBL29887032 | 0.75 | PI4KA (0.48) | EGFRSIGMAR1BTKAKT1AKT2 | |
| SCHEMBL13762806 | 0.75 | PI4KA (0.54) | EGFRSIGMAR1BTKAKT1AKT2 | |
| SCHEMBL27731637 | 0.74 | EGFR (0.50) | EGFRSIGMAR1BTKAKT1AKT2 | |
| SCHEMBL30164318 | 0.72 | EGFR (0.47) | EGFRSIGMAR1BTKAKT1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1973917-A2 | PROTEIN KINASE INHIBITORS | Abbott Laboratories (US) | 2008-10-01 | — | — | EP | disclosed |
| WO-2007079164-A2 | PROTEIN KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2007-07-12 | — | — | WO | disclosed |