Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 17/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4975970 | 0.93 | MERTK (0.43) | TTKPDE5APDGFRAFLT3 | |
| SCHEMBL4972483 | 0.90 | TTK (0.46) | TTKADORA3ADORA1 | |
| SCHEMBL4766859 | 0.89 | TTK (0.48) | TTKADORA3PDGFRAFLT3PIK3CB | |
| SCHEMBL10270818 | 0.89 | TTK (0.49) | TTKPIK3CBMAPK8PTK2 | |
| SCHEMBL4767272 | 0.85 | TTK (0.39) | TTKADORA3ADORA1 | |
| SCHEMBL4974126 | 0.84 | TTK (0.45) | TTK | |
| SCHEMBL4977877 | 0.84 | CSF1R (0.49) | TTKPDGFRAFLT3 | |
| SCHEMBL4975631 | 0.84 | TTK (0.43) | TTKADORA3ADORA1PIK3CBMAPK8 | |
| SCHEMBL4977265 | 0.82 | TTK (0.49) | TTKPDGFRAFLT3 | |
| SCHEMBL4766802 | 0.81 | TTK (0.50) | TTKADORA3ADORA1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120122840-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYREXIS, INC. (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122840-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | VHL, TP53, ASAH2 | TTK 4589/4885ADORA3 1744/4885ADORA1 2771/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.