Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 15/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | MERTK | Q12866 | 2/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4766540 | 0.95 | TTK (0.57) | TTK | |
| SCHEMBL4979254 | 0.94 | TTK (0.58) | TTKMERTKLRRK2AXLTYRO3 | |
| SCHEMBL4979599 | 0.94 | MERTK (0.51) | TTKCSF1RMERTKAXL | |
| SCHEMBL4974126 | 0.92 | TTK (0.45) | TTKCSF1RMERTKLRRK2 | |
| SCHEMBL4973381 | 0.92 | TTK (0.46) | TTKCSF1RMERTK | |
| SCHEMBL4979276 | 0.91 | TTK (0.45) | TTKCSF1RMERTK | |
| SCHEMBL4977877 | 0.90 | CSF1R (0.49) | TTKCSF1RMERTKLRRK2 | |
| SCHEMBL10270515 | 0.90 | LRRK2 (0.55) | TTKCSF1RLRRK2 | |
| SCHEMBL4974171 | 0.88 | TTK (0.48) | TTKMERTKLRRK2AXLTYRO3 | |
| SCHEMBL4766802 | 0.88 | TTK (0.50) | TTKMERTKAXLTYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120122840-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYREXIS, INC. (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122840-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | VHL, TP53, ASAH2 | TTK 4589/4885CSF1R 4296/4885MERTK 1662/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.