Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 19/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 8/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.58 |
| ▸ | KIT | P10721 | 5/20 | 0.54 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.54 |
| ▸ | PLK4 | O00444 | 2/20 | 0.54 |
| ▸ | STK25 | O00506 | 2/20 | 0.54 |
| ▸ | RIOK3 | O14730 | 2/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.54 |
| ▸ | GAK | O14976 | 2/20 | 0.54 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.54 |
| ▸ | MUSK | O15146 | 2/20 | 0.54 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.54 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.54 |
| ▸ | MAP3K13 | O43283 | 2/20 | 0.54 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.54 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.54 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.54 |
| ▸ | JAK2 | O60674 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13105789 | 0.96 | CSF1R (0.79) | CSF1RCYP3A4CYP2C19CYP2C9KIT | |
| Trifluoroacetic Acid SCHEMBL4986981 | 0.93 | CSF1R (0.70) | CSF1RCYP3A4CYP2C19CYP2C9KIT | |
| Trifluoroacetic Acid SCHEMBL4980854 | 0.89 | CSF1R (0.72) | CSF1RCYP3A4CYP2C19CYP2C9KIT | |
| SCHEMBL13105931 | 0.88 | CSF1R (0.77) | CSF1RCYP3A4CYP2C19CYP2C9KIT | |
| Trifluoroacetic Acid SCHEMBL4983994 | 0.87 | CSF1R (0.59) | CSF1RCYP3A4CYP2C19CYP2C9KIT | |
| SCHEMBL18240976 | 0.85 | CSF1R (0.68) | CSF1RCYP3A4CYP2C19CYP2C9KIT | |
| SCHEMBL2943557 | 0.85 | CSF1R (0.78) | CSF1RCYP3A4CYP2C19CYP2C9KIT | |
| SCHEMBL13523823 | 0.84 | CSF1R (0.59) | CSF1RCYP3A4CYP2C19CYP2C9KIT | |
| SCHEMBL5142360 | 0.84 | CSF1R (0.79) | CSF1RCYP3A4CYP2C19CYP2C9KIT | |
| Trifluoroacetic Acid SCHEMBL2943105 | 0.84 | CSF1R (0.69) | CSF1RCYP3A4CYP2C19CYP2C9KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8697716-B2 | Method of inhibiting C-KIT kinase | JANSSEN PHARMACEUTICA NV (BE) | 2014-04-15 | — | — | US | disclosed |
| US-20080051402-A1 | METHOD OF INHIBITING C-KIT KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2008-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051402-A1 | METHOD OF INHIBITING C-KIT KINASE | KIT, CHUK, MAP3K13 | CSF1R 2973/4885CYP3A4 4130/4885CYP2C19 4271/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.