Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 11/20 | 0.48 |
| ▸ | SRC | P12931 | 7/20 | 0.47 |
| ▸ | EGFR | P00533 | 10/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 6/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.43 |
| ▸ | ABL1 | P00519 | 4/20 | 0.43 |
| ▸ | HCK | P08631 | 4/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.43 |
| ▸ | MTOR | P42345 | 4/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.43 |
| ▸ | EPHB4 | P54760 | 4/20 | 0.43 |
| ▸ | PRKDC | P78527 | 4/20 | 0.43 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.43 |
| ▸ | LCK | P06239 | 2/20 | 0.43 |
| ▸ | TEK | Q02763 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2968796 | 0.86 | IGF1R (0.59) | IGF1RSRCEGFRERBB2KDR | |
| SCHEMBL2968823 | 0.82 | IGF1R (0.58) | IGF1RSRCEGFRERBB2CYP2D6 | |
| Tert-Butyl Formate SCHEMBL28775137 | 0.82 | SRC (0.54) | IGF1RSRCEGFRERBB2KDR | |
| SCHEMBL2963758 | 0.81 | IGF1R (0.62) | IGF1RSRCEGFRERBB2CYP2D6 | |
| SCHEMBL2956093 | 0.80 | IGF1R (0.68) | IGF1RSRCEGFRERBB2CYP2D6 | |
| SCHEMBL2966523 | 0.80 | IGF1R (0.68) | IGF1RSRCEGFRERBB2CYP2D6 | |
| SCHEMBL2956094 | 0.80 | IGF1R (0.68) | IGF1RSRCEGFRERBB2CYP2D6 | |
| SCHEMBL27733903 | 0.80 | IGF1R (0.63) | IGF1RSRCEGFRERBB2CYP2D6 | |
| SCHEMBL2960269 | 0.79 | IGF1R (0.61) | IGF1RSRCEGFRERBB2CYP2D6 | |
| SCHEMBL2960270 | 0.79 | IGF1R (0.61) | IGF1RSRCEGFRERBB2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1973917-A2 | PROTEIN KINASE INHIBITORS | Abbott Laboratories (US) | 2008-10-01 | — | — | EP | disclosed |
| WO-2007079164-A2 | PROTEIN KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2007-07-12 | — | — | WO | disclosed |