Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 6/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5527481 | 0.89 | SMN1; SMN2 (0.56) | PDE11APDE10ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4973198 | 0.84 | HDAC1 (0.45) | PDE11APDE10ANPC1RAB9AHDAC1 | |
| SCHEMBL4970218 | 0.84 | HDAC1 (0.52) | NPC1RAB9ASMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL4980057 | 0.83 | HDAC1 (0.62) | PDE11APDE10ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4981752 | 0.83 | HDAC2 (0.43) | PDE11APDE10ANPC1RAB9AHDAC1 | |
| SCHEMBL4981319 | 0.82 | HDAC2 (0.42) | PDE11APDE10ANPC1RAB9AHDAC1 | |
| SCHEMBL3534129 | 0.78 | HDAC1 (0.58) | NPC1ALDH1A1HDAC1HDAC2MEN1 | |
| SCHEMBL8230897 | 0.76 | HDAC1 (0.52) | HDAC1HDAC2MEN1MAPK1KMT2A | |
| SCHEMBL9910547 | 0.76 | PDE11A (0.58) | PDE11APDE10ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4983837 | 0.76 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2ALDH1A1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070173527-A1 | HISTONE DEACETYLASE INHIBITORS | TAKEDA SAN DIEGO, INC. | 2007-07-26 | — | — | US | claimed |
| EP-1976835-A2 | HISTONE DEACETYLASE INHIBITORS | Takeda San Diego, Inc. (US) | 2008-10-08 | — | — | EP | disclosed |
| WO-2007084390-A2 | HISTONE DEACETYLASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2007-07-26 | — | — | WO | disclosed |
| US-20070173527-A1 | HISTONE DEACETYLASE INHIBITORS | TAKEDA SAN DIEGO, INC. | 2007-07-26 | — | — | US | disclosed |
| US-20070173527-A1 | HISTONE DEACETYLASE INHIBITORS | TAKEDA SAN DIEGO, INC. | 2007-07-26 | — | — | US | disclosed |
| US-20070173527-A1 | HISTONE DEACETYLASE INHIBITORS | TAKEDA SAN DIEGO, INC. | 2007-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070173527-A1 | HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC3, HDAC2 | PDE11A 2878/4885PDE10A 2845/4885NPC1 1565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.