Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 19/20 | 0.78 |
| ▸ | JAK2 | O60674 | 18/20 | 0.78 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | STK10 | O94804 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FER | P16591 | 1/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | STAT5A | P42229 | 1/20 | 0.41 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.41 |
| ▸ | STK4 | Q13043 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4980318 | 1.00 | JAK3 (0.78) | JAK3JAK2AURKAPLK4STK10 | |
| SCHEMBL4983431 | 0.96 | JAK2 (0.72) | JAK3JAK2AURKAPLK4STK10 | |
| SCHEMBL4982528 | 0.88 | JAK2 (0.61) | JAK3JAK2PLK4PAK4 | |
| SCHEMBL4982538 | 0.88 | JAK2 (0.61) | JAK3JAK2PLK4PAK4 | |
| SCHEMBL13943164 | 0.86 | JAK3 (0.58) | JAK3JAK2AURKAPLK4STK10 | |
| SCHEMBL4978667 | 0.80 | JAK3 (0.62) | JAK3JAK2PLK4PAK4RET | |
| SCHEMBL13943439 | 0.78 | JAK3 (0.60) | JAK3JAK2AURKAPLK4STK10 | |
| SCHEMBL4977038 | 0.77 | JAK2 (0.78) | JAK3JAK2 | |
| SCHEMBL4982598 | 0.77 | JAK2 (0.78) | JAK3JAK2 | |
| SCHEMBL4985706 | 0.77 | JAK2 (0.58) | JAK3JAK2AURKAPAK4AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008132502-A1 | PYRAZOLYL-AMINO-SUBSTITUTED PYRIMIDINES AND THEIR USE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-11-06 | — | — | WO | disclosed |