⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL497629 | 0.90 | PDPK1 (0.45) | — | |
| SCHEMBL1606338 | 0.88 | PDPK1 (0.43) | — | |
| SCHEMBL5810324 | 0.86 | PDPK1 (0.42) | — | |
| SCHEMBL102331 | 0.80 | PDPK1 (0.59) | — | |
| SCHEMBL30632310 | 0.77 | PDPK1 (0.56) | — | |
| SCHEMBL28154527 | 0.77 | PDPK1 (0.56) | — | |
| SCHEMBL31556353 | 0.77 | PDPK1 (0.56) | — | |
| SCHEMBL30534095 | 0.77 | PDPK1 (0.56) | — | |
| SCHEMBL722198 | 0.70 | PDPK1 (0.77) | — | |
| SCHEMBL28865526 | 0.69 | PDPK1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3442977-B1 | INHIBITORS OF ACTIVIN RECEPTOR-LIKE KINASE | BLUEPRINT MEDICINES CORP (US) | 2023-06-28 | — | — | EP | claimed |
| EP-3442977-A1 | INHIBITORS OF ACTIVIN RECEPTOR-LIKE KINASE | Blueprint Medicines Corporation (US) | 2019-02-20 | — | — | EP | claimed |
| CN-109311889-A | Activin receptor-like kinase inhibitors | 蓝图药品公司 | 2019-02-05 | — | — | CN | claimed |
| WO-2017181117-A1 | INHIBITORS OF ACTIVIN RECEPTOR-LIKE KINASE | BLUEPRINT MEDICINES CORPORATION (US) | 2017-10-19 | — | — | WO | claimed |
| US-6515025-B2 | Renin inhibitor | PHARMACIA CORPORATION | 2003-02-04 | — | — | US | claimed |
| US-20020025934-A1 | Ethynyl alanine amino diol compounds for treatment of hypertension | G.D. SEARLE & CO. (US) | 2002-02-28 | — | — | US | claimed |
| US-6281235-B1 | CONTROL OF HYPERTENSION. | G.D. SEARLE & CO. | 2001-08-28 | — | — | US | claimed |
| US-6174923-B1 | ADMINISTERING ETHYNYL ALANINE AMINO DIOL COMPOUND FOR TREATING HYPERTENSION | G. D. SEARLE & CO. | 2001-01-16 | — | — | US | claimed |
| US-5942548-A | ACT AS RENIN INHIBITORS; ADMINISTERING TO TREAT CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1999-08-24 | — | — | US | claimed |
| US-5849773-A | Amino acyl amino propargyl diol compounds for treatment of hypertension | G. D. SEARLE & CO. (US) | 1998-12-15 | — | — | US | claimed |
| US-5508295-A | RENIN INHIBITORS | G. D. SEARLE & CO. (US) | 1996-04-16 | — | — | US | claimed |
| US-5484811-A | ADMINISTERING A RENIN INHIBITOR TO A SUBJECT | G. D. SEARLE & CO. (US) | 1996-01-16 | — | — | US | claimed |
| EP-0610451-A1 | ETHYNYL ALANINE AMINO DIOL COMPOUNDS FOR TREATMENT OF HYPERTENSION | G.D. SEARLE & CO. (US) | 1994-08-17 | — | — | EP | claimed |
| US-5330996-A | Renin inhibitors | G. D. SEARLE & CO. (US) | 1994-07-19 | — | — | US | claimed |
| US-5227401-A | ETHYNYL ALANINE AMINO DIOL COMPOUNDS FOR TREATMENT OF HYPERTENSION | G. D. SEARLE & CO. (US) | 1993-07-13 | — | — | US | claimed |
| WO-1993009108-A1 | AMINO ACYL AMINO PROPARGYL DIOL COMPOUNDS FOR TREATMENT OF HYPERTENSION | G.D. SEARLE & CO. (US) | 1993-05-13 | — | — | WO | claimed |
| WO-1993009087-A1 | ETHYNYL ALANINE AMINO DIOL COMPOUNDS FOR TREATMENT OF HYPERTENSION | G.D. SEARLE & CO. (US) | 1993-05-13 | — | — | WO | claimed |
| EP-0539976-A1 | Ethynyl-alanine-amino-diol compounds for treatment of hypertension | G.D. Searle & Co. (US) | 1993-05-05 | — | — | EP | claimed |
| US-20240158398-A1 | INHIBITORS OF ACTIVIN RECEPTOR-LIKE KINASE | BLUEPRINT MEDICINES CORPORATION | 2024-05-16 | — | — | US | disclosed |
| EP-0539976-A1 | Ethynyl-alanine-amino-diol compounds for treatment of hypertension | G.D. Searle & Co. (US) | 1993-05-05 | — | — | EP | disclosed |