⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1515198 | 0.84 | — | — | |
| SCHEMBL497933 | 0.84 | — | — | |
| SCHEMBL7717442 | 0.81 | — | — | |
| SCHEMBL6409752 | 0.67 | — | — | |
| SCHEMBL21609451 | 0.60 | — | — | |
| SCHEMBL10276 | 0.46 | — | — | |
| SCHEMBL23044067 | 0.45 | — | — | |
| SCHEMBL2339 | 0.45 | — | — | |
| SCHEMBL11038950 | 0.41 | — | — | |
| SCHEMBL26810 | 0.41 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 261 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4395890-A1 | COMPOUNDS AND METHODS FOR MODULATING SPLICING | Remix Therapeutics Inc. (US) | 2024-07-10 | — | — | EP | claimed |
| US-11655243-B2 | Pyridine and pyrazine derivatives as preferential cannabinoid 2 agonists | HOFFMANN-LA ROCHE INC. (US) | 2023-05-23 | — | — | US | claimed |
| WO-2023034836-A1 | COMPOUNDS AND METHODS FOR MODULATING SPLICING | REMIX THERAPEUTICS INC. (US) | 2023-03-09 | — | — | WO | claimed |
| EP-3814337-A1 | PYRIDINE AND PYRAZINE DERIVATIVES AS PREFERENTIAL CANNABINOID 2 AGONISTS | F. Hoffmann-La Roche AG (CH) | 2021-05-05 | — | — | EP | claimed |
| US-20210115027-A1 | PYRIDINE AND PYRAZINE DERIVATIVES AS PREFERENTIAL CANNABINOID 2 AGONISTS | HOFFMANN-LA ROCHE INC. (US) | 2021-04-22 | — | — | US | claimed |
| CN-112074513-A | Pyridine and pyrazine derivatives as preferential cannabinoid 2 agonists | 豪夫迈·罗氏有限公司 | 2020-12-11 | — | — | CN | claimed |
| EP-3478674-B1 | 4,6-DIAMINOQUINAZOLINES AS COT MODULATORS AND METHODS OF USE THEREOF | GILEAD SCIENCES INC (US) | 2020-05-13 | — | — | EP | claimed |
| US-10577352-B2 | Cot modulators and methods of use thereof | GILEAD SCIENCES, INC. (US) | 2020-03-03 | — | — | US | claimed |
| WO-2020002270-A1 | PYRIDINE AND PYRAZINE DERIVATIVES AS PREFERENTIAL CANNABINOID 2 AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2020-01-02 | — | — | WO | claimed |
| EP-3478674-A1 | 4,6-DIAMINOQUINAZOLINES AS COT MODULATORS AND METHODS OF USE THEREOF | Gilead Sciences, Inc. (US) | 2019-05-08 | — | — | EP | claimed |
| US-20190016705-A1 | COT MODULATORS AND METHODS OF USE THEREOF | GILEAD SCIENCES, INC. | 2019-01-17 | — | — | US | claimed |
| US-10059695-B2 | Cot modulators and methods of use thereof | GILEAD SCIENCES, INC. (US) | 2018-08-28 | — | — | US | claimed |
| CN-104854092-B | Pyridine-2-amides useful as CB2 agonists | 霍夫曼-拉罗奇有限公司 | 2018-08-10 | — | — | CN | claimed |
| US-20180002316-A1 | COT MODULATORS AND METHODS OF USE THEREOF | GILEAD SCIENCES, INC. | 2018-01-04 | — | — | US | claimed |
| WO-2018005435-A1 | 4,6-DIAMINOQUINAZOLINES AS COT MODULATORS AND METHODS OF USE THEREOF | GILEAD SCIENCES, INC. (US) | 2018-01-04 | — | — | WO | claimed |
| EP-1102767-B1 | SUBSTITUTED PYRAZOLE DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2005-11-02 | — | — | EP | claimed |
| CN-1571669-A | Novel combination | BUYER MEDICINE AND HEALTH CARE (DE) | 2005-01-26 | — | — | CN | claimed |
| US-6833364-B1 | Inhibiting degradation of cyclic guanosine monophosphate; cardiovascular disorders; such as 3-(4-amino-5-cyclopropyl-pyrimidin-2-yl)-1-(2-fluorobenzyl)1H-pyrazolo-(3,4 -b)-pyridine | BAYER HEALTHCARE AG (DE) | 2004-12-21 | — | — | US | claimed |
| US-20040186163-A1 | Novel combination | BAYER HEALTHCARE AG (DE) | 2004-09-23 | — | — | US | claimed |
| US-20040053915-A1 | Use of stimulators of soluble guanylate cyclase for treating osteoporosis | BAYER AKTIENGESELLSCHAFT (DE) | 2004-03-18 | — | — | US | claimed |