Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 20/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.45 |
| ▸ | STRADA | Q7RTN6 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4982763 | 0.88 | MAPK14 (0.50) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL4497444 | 0.88 | MAPK14 (0.51) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL4504739 | 0.85 | MAPK14 (0.46) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL4514115 | 0.80 | MAPK14 (0.70) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL13678572 | 0.79 | MAPK14 (0.43) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL5269088 | 0.79 | MAPK14 (0.62) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL5267558 | 0.78 | MAPK14 (0.62) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL5334379 | 0.77 | MAPK14 (0.60) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL4507620 | 0.76 | MAPK14 (0.56) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL13603337 | 0.76 | MAPK14 (0.47) | MAPK14MAPK11ROCK2MAPK12STRADA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1987022-A1 | PYRIDINONE PYRAZOLE UREA AND PYRIMIDINONE PYRAZOLE UREA DERIVATIVES | Pfizer Products Inc. (US) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007091176-A1 | PYRIDINONE PYRAZOLE UREA AND PYRIMIDINONE PYRAZOLE UREA DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2007-08-16 | — | — | WO | disclosed |