Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 8/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isopropyl Alcohol SCHEMBL4984693 | 0.97 | PIK3CG (0.50) | PIK3CGTSHRMAPK10CNR1MEN1 | |
| SCHEMBL8230137 | 0.95 | PIK3CG (0.48) | PIK3CGTSHRMAPK10CNR1MEN1 | |
| SCHEMBL8231088 | 0.94 | PIK3CG (0.49) | PIK3CGTSHRMAPK10CNR1MEN1 | |
| SCHEMBL8237567 | 0.92 | PIK3CG (0.49) | PIK3CGTSHRMAPK10CNR1MEN1 | |
| SCHEMBL4328277 | 0.90 | PIK3CG (0.50) | PIK3CGTSHRMAPK10CNR1PARP1 | |
| Citric Acid SCHEMBL4339096 | 0.85 | TSHR (0.44) | PIK3CGTSHRMAPK10CNR1MEN1 | |
| SCHEMBL4334685 | 0.85 | PIK3CG (0.60) | PIK3CGTSHRMAPK10CNR1PARP1 | |
| Citric Acid SCHEMBL4333388 | 0.84 | TSHR (0.43) | PIK3CGTSHRMAPK10CNR1MEN1 | |
| Citric Acid SCHEMBL4327809 | 0.82 | PIK3CG (0.41) | PIK3CGTSHRMAPK10CNR1MEN1 | |
| SCHEMBL2026420 | 0.81 | PIK3CG (0.66) | PIK3CGPIK3CDPIK3R1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1986998-A1 | METABOTROPIC GLUTAMATE RECEPTOR-POTENTIATING SOINDOLONES | AstraZeneca AB (SE) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007095024-A1 | METABOTROPIC GLUTAMATE RECEPTOR-POTENTIATING ΓSOINDOLONES | ASTRAZENECA AB (SE) | 2007-08-23 | — | — | WO | disclosed |