Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 15/20 | 0.61 |
| ▸ | JAK3 | P52333 | 15/20 | 0.61 |
| ▸ | PLK4 | O00444 | 3/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.34 |
| ▸ | MUSK | O15146 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4981367 | 0.96 | JAK2 (0.57) | JAK2JAK3PLK4PAK4NTRK1 | |
| SCHEMBL4983520 | 0.91 | JAK3 (0.63) | JAK2JAK3PLK4PAK4NTRK1 | |
| SCHEMBL4983862 | 0.88 | JAK3 (0.79) | JAK2JAK3PLK4PAK4NTRK1 | |
| SCHEMBL4979167 | 0.86 | JAK2 (0.63) | JAK2JAK3PLK4PAK4NTRK1 | |
| SCHEMBL4978667 | 0.86 | JAK3 (0.62) | JAK2JAK3PLK4PAK4RET | |
| SCHEMBL4982454 | 0.82 | JAK2 (0.75) | JAK2JAK3NTRK1CDK2 | |
| SCHEMBL4978435 | 0.82 | JAK2 (0.75) | JAK2JAK3NTRK1CDK2 | |
| SCHEMBL4985706 | 0.82 | JAK2 (0.58) | JAK2JAK3PAK4 | |
| SCHEMBL4971410 | 0.82 | JAK2 (0.36) | JAK2JAK3 | |
| SCHEMBL3946105 | 0.81 | JAK3 (0.46) | JAK2JAK3PLK4PAK4NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008132502-A1 | PYRAZOLYL-AMINO-SUBSTITUTED PYRIMIDINES AND THEIR USE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-11-06 | — | — | WO | disclosed |