Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.60 |
| ▸ | NSD2 | O96028 | 2/20 | 0.50 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.46 |
| ▸ | EHMT1 | Q9H9B1 | 2/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14122880 | 0.88 | KDR (0.57) | KDRNSD2SSTR5SIGMAR1KIT | |
| SCHEMBL4989253 | 0.87 | KDR (0.56) | KDRNSD2SSTR5 | |
| SCHEMBL14123086 | 0.87 | KDR (0.56) | KDRNSD2SSTR5SIGMAR1ACHE | |
| SCHEMBL14122883 | 0.86 | DRD4 (0.58) | KDRNSD2SSTR5SIGMAR1ACHE | |
| SCHEMBL4302009 | 0.85 | KDR (0.53) | KDRSIGMAR1KITPDGFRATSHR | |
| SCHEMBL4297583 | 0.84 | KDR (0.59) | KDRKITPDGFRA | |
| SCHEMBL14122915 | 0.83 | KDR (0.56) | KDRSIGMAR1KITPDGFRATSHR | |
| SCHEMBL14122952 | 0.82 | KDR (0.55) | KDRKITPDGFRA | |
| SCHEMBL4300937 | 0.81 | KDR (0.50) | KDRNSD2ACHEEHMT2EHMT1 | |
| SCHEMBL4983392 | 0.76 | KDR (0.45) | KDRKITPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8338455-B2 | Pyridines or pyrimidines having 4-(hydrogenated 1-pyridyl- or hydrogenated 1-isoquinolyl rings, e.g., N-(4-chlorophenyl)-2-(pyridin-4-ylmethyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxamide; kinase inhibitors; inflammation, angiogenesis and cancer | AMGEN INC. (US) | 2012-12-25 | — | — | US | disclosed |
| EP-2118088-B1 | Heterocyclic compounds and their use in treating inflammation, angiogenesis and cancer | AMGEN INC (US) | 2012-05-30 | — | — | EP | disclosed |
| US-20080161346-A1 | Compounds and methods of use | AMGEN INC. (US) | 2008-07-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161346-A1 | Compounds and methods of use | VHL, VEGFA, FLT1 | KDR 6/4885NSD2 4626/4885SSTR5 768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.