Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 12/20 | 0.44 |
| ▸ | PDE4A | P27815 | 11/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL873439 | 0.88 | PDE4A (0.45) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL873809 | 0.86 | PDE4B (0.46) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL874555 | 0.85 | PDE4B (0.46) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL874226 | 0.84 | PDE4A (0.47) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL873397 | 0.84 | PDE4A (0.42) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL873453 | 0.84 | PDE4A (0.42) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| SCHEMBL874590 | 0.84 | PDE4A (0.41) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL873932 | 0.83 | PDE4A (0.41) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL873724 | 0.83 | PDE4B (0.46) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| SCHEMBL16476087 | 0.83 | PDE4B (0.46) | PDE4BPDE4APDE4CPDE4DMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1989188-A1 | THERAPEUTIC PIPERAZINES AS PDE4 INHIBITORS | Helicon Therapeutics, Inc. (US) | 2008-11-12 | — | — | EP | disclosed |
| WO-2007100852-A1 | THERAPEUTIC PIPERAZINES AS PDE4 INHIBITORS | HELICON THERAPEUTICS, INC. (US) | 2007-09-07 | — | — | WO | disclosed |