Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 4/20 | 0.41 |
| ▸ | XIAP | P98170 | 2/20 | 0.39 |
| ▸ | BIRC2 | Q13490 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL753914 | 0.81 | NR3C2 (0.46) | NR3C2XIAPBIRC2ELANEMAPT | |
| SCHEMBL755954 | 0.78 | NR3C2 (0.46) | NR3C2XIAPBIRC2ELANEKMT2A | |
| SCHEMBL4527010 | 0.77 | NR3C2 (0.51) | NR3C2XIAPBIRC2L3MBTL1MAPT | |
| SCHEMBL758027 | 0.74 | NR3C2 (0.39) | NR3C2XIAPBIRC2F2F10 | |
| SCHEMBL753325 | 0.73 | NR3C2 (0.74) | NR3C2XIAPBIRC2 | |
| SCHEMBL4989058 | 0.67 | NR3C2 (0.46) | NR3C2MAPTMEN1KMT2ATP53 | |
| SCHEMBL18581135 | 0.67 | XIAP (0.37) | NR3C2XIAPBIRC2MAPTALDH1A1 | |
| SCHEMBL15049883 | 0.66 | MAOB (0.35) | KDM4EMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL9139749 | 0.65 | ELANE (0.46) | NR3C2L3MBTL1ELANEKDM4EMAPT | |
| SCHEMBL756843 | 0.65 | NR3C2 (0.63) | NR3C2MAPTAPAF1HSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984345-A1 | BENZOXAZINES AND RELATED NITROGEN-CONTAINING HETEROBICYCLIC COMPOUNDS USEFUL AS MINERALOCORTICOID RECEPTOR MODULATING AGENTS | Mitsubishi Tanabe Pharma Corporation (JP) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007089034-A1 | BENZOXAZINES AND RELATED NITROGEN-CONTAINING HETEROBICYCLIC COMPOUNDS USEFUL AS MINERALOCORTICOID RECEPTOR MODULATING AGENTS | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2007-08-09 | — | — | WO | disclosed |