Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 14/20 | 0.46 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | TTK | P33981 | 2/20 | 0.40 |
| ▸ | MARK3 | P27448 | 4/20 | 0.40 |
| ▸ | MARK4 | Q96L34 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2397220 | 0.82 | MARK3 (0.50) | PLK1BRD4BRDTPARP1TTK | |
| SCHEMBL2400703 | 0.81 | PLK1 (0.51) | PLK1BRD4BRDTTTKMARK3 | |
| SCHEMBL2396957 | 0.80 | PLK1 (0.47) | PLK1BRD4BRDTPARP1TTK | |
| SCHEMBL2396937 | 0.80 | MARK3 (0.59) | PLK1BRD4BRDTTTKMARK3 | |
| SCHEMBL2395765 | 0.80 | PLK1 (0.52) | PLK1BRD4BRDTMARK3MARK4 | |
| SCHEMBL2396917 | 0.79 | PLK1 (0.63) | PLK1BRD4BRDT | |
| SCHEMBL2396972 | 0.79 | PLK1 (0.54) | PLK1BRD4BRDT | |
| SCHEMBL9945383 | 0.79 | PLK1 (0.53) | PLK1BRD4BRDTTTKMARK3 | |
| SCHEMBL2396655 | 0.78 | PIK3CA (0.50) | PLK1BRD4BRDTMARK3MARK4 | |
| SCHEMBL2396517 | 0.78 | PLK1 (0.49) | PLK1BRD4BRDTMARK3MARK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1983987-A2 | DIHYDRODIAZEPINES USEFUL AS INHIBITORS OF PROTEIN KINASES | Vertex Pharmaceuticals Incorporated (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007095188-A2 | DIHYDRODIAZEPINES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-08-23 | — | — | WO | disclosed |