SCHEMBL4987443

SCHEMBL4987443

Clc1ccc2c(c1)c(Sc1ccccc1)cn2-c1ccc2cobc2c1

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PTGDR2 Q9Y5Y4 1/20 0.41
MEN1 O00255 1/20 0.32
CYP3A4 P08684 1/20 0.32
MAPT P10636 1/20 0.32
ALOX15 P16050 1/20 0.32
TSHR P16473 1/20 0.32
ALOX12 P18054 1/20 0.32
PPARG P37231 1/20 0.32
RECQL P46063 1/20 0.32
BLM P54132 1/20 0.32
KMT2A Q03164 1/20 0.32
HSD17B10 Q99714 1/20 0.32
KCNH2 Q12809 8/20 0.32
RHEB Q15382 1/20 0.32
PDE7A Q13946 1/20 0.32
PDE7B Q9NP56 1/20 0.32
CPT2 P23786 1/20 0.30
CPT1A P50416 1/20 0.30
CPT1B Q92523 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4557434 0.79 PTGDR2 (0.50) PTGDR2MEN1CYP3A4MAPTALOX15
SCHEMBL594829 0.72 PTGDR2 (0.44) PTGDR2MEN1CYP3A4MAPTALOX15
SCHEMBL16682431 0.71 PTGDR2 (0.39) PTGDR2MEN1CYP3A4MAPTALOX15
SCHEMBL596180 0.71 CA1 (0.46) PTGDR2
SCHEMBL10172261 0.69 PTGDR2 (0.40) PTGDR2MEN1CYP3A4MAPTALOX15
SCHEMBL10268362 0.68 CPT1A (0.53) PTGDR2MEN1CYP3A4MAPTALOX15
SCHEMBL14470724 0.67 PTGDR2 (0.61) PTGDR2MEN1CYP3A4MAPTALOX15
SCHEMBL21027884 0.66 PTGDR2 (0.49) PTGDR2MEN1CYP3A4MAPTALOX15
SCHEMBL10172212 0.65 PTGDR2 (0.48) PTGDR2MEN1CYP3A4MAPTALOX15
SCHEMBL13470741 0.62 PTGDR2 (0.47) PTGDR2MEN1CYP3A4MAPTALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1988779-A2 BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS Anacor Pharmaceuticals, Inc. (US) 2008-11-12 EP disclosed
WO-2007095638-A2 BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS ANACOR PHARMACEUTICALS, INC. (US) 2007-08-23 WO disclosed