Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL499965 | 0.80 | HTR2C (0.35) | HTR2CSLC6A4ALDH1A1POLBHSD17B10 | |
| SCHEMBL8110118 | 0.79 | SYK (0.46) | KMT2ACTSLCTSBCTSSMEN1 | |
| SCHEMBL499680 | 0.78 | ATM (0.38) | RORCATMKMT2AMEN1ALDH1A1 | |
| SCHEMBL499442 | 0.76 | HTR2C (0.31) | HTR2CSLC6A4CTSLCTSBCTSS | |
| SCHEMBL13242430 | 0.76 | HTR2C (0.31) | HTR2CSLC6A4CTSLCTSBCTSS | |
| SCHEMBL2025474 | 0.75 | SYK (0.43) | KMT2ACTSLCTSBCTSSMEN1 | |
| SCHEMBL2025069 | 0.75 | SYK (0.43) | KMT2ACTSLCTSBCTSSMEN1 | |
| SCHEMBL2023544 | 0.75 | SYK (0.43) | KMT2ACTSLCTSBCTSSMEN1 | |
| SCHEMBL7992205 | 0.75 | SYK (0.43) | KMT2ACTSLCTSBCTSSMEN1 | |
| SCHEMBL2022224 | 0.75 | SYK (0.43) | KMT2ACTSLCTSBCTSSMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106221-B2 | Renin inhibitors | VITAE PHARMACEUTICALS, INC. (US) | 2012-01-31 | — | — | US | disclosed |