Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 7/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | CASP1 | P29466 | 1/20 | 0.55 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.55 |
| ▸ | TTR | P02766 | 1/20 | 0.55 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.49 |
| ▸ | BCHE | P06276 | 2/20 | 0.48 |
| ▸ | TGM2 | P21980 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30070852 | 1.00 | CES1 (1.00) | CES1ALDH1A1MAPTMEN1KMT2A | |
| Nitrogen SCHEMBL27935041 | 0.95 | CES1 (0.90) | CES1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL9917546 | 0.86 | CES1 (0.76) | CES1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL19747937 | 0.86 | CES1 (0.76) | CES1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL9917537 | 0.86 | CES1 (0.76) | CES1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL9236314 | 0.84 | CES1 (0.72) | CES1ALDH1A1MEN1KMT2ATTR | |
| SCHEMBL27686651 | 0.84 | CES1 (0.72) | CES1ALDH1A1MEN1KMT2ATTR | |
| SCHEMBL5739235 | 0.82 | CES1 (0.70) | CES1ALDH1A1TTRCTRB1BCHE | |
| SCHEMBL25707024 | 0.82 | CES1 (0.70) | CES1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL31107464 | 0.81 | CES1 (0.69) | CES1ALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10065927-B2 | α-ketoacylic isoniazid compounds, process for producing said compounds, use of the compounds in the treatment of tuberculosis | Fundacão Oswaldo Cruz (FIOCRUZ) (BR) | 2018-09-04 | — | — | US | claimed |
| CN-103554117-B | A kind of preparation method of chiral spiro naphthoquinone benzopyran hydroxyindole compound | ZHANGJIAGANG INSTITUTE OF INDUSTRIAL TECHNOLOGIES SOOCHOW UNIVERSITY (CN) | 2015-09-23 | — | — | CN | claimed |
| CN-103554117-A | Preparation method of chiral spiro naphthoquinone benzopyran hydroxyindole compound | ZHANGJIAGANG INST IND TECHNOLOGIES SOOCHOW UNIV | 2014-02-05 | — | — | CN | claimed |
| CN-118459390-B | 3-Hydroxy oxindole derivative containing Z-type 1, 4-dicarbonyl olefin, and preparation method and application thereof | SUN YAT-SEN UNIVERSITY (CN) | 2026-05-26 | — | — | CN | disclosed |
| CN-118459390-A | 3-Hydroxy oxindole derivative containing Z-type 1, 4-dicarbonyl olefin, and preparation method and application thereof | 中山大学 | 2024-08-09 | — | — | CN | disclosed |
| WO-2023219456-A1 | QUINOLINE-BASED HISTONE DEACETYLASE INHIBITORY SUBSTANCES, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME AS ACTIVE INGREDIENT | 숙명여자대학교 산학협력단 | 2023-11-16 | — | — | WO | disclosed |
| WO-2023219456-A1 | QUINOLINE-BASED HISTONE DEACETYLASE INHIBITORY SUBSTANCES, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME AS ACTIVE INGREDIENT | 숙명여자대학교 산학협력단 | 2023-11-16 | — | — | WO | disclosed |
| US-20230183391-A1 | BIOMASS DERIVED DIKETONES AS EFFICIENT VISIBLE LIGHT PHOTOINITIATORS | BOWLING GREEN STATE UNIVERSITY (US) | 2023-06-15 | — | — | US | disclosed |
| US-20230183391-A1 | BIOMASS DERIVED DIKETONES AS EFFICIENT VISIBLE LIGHT PHOTOINITIATORS | BOWLING GREEN STATE UNIVERSITY (US) | 2023-06-15 | — | — | US | disclosed |
| US-20230183391-A1 | BIOMASS DERIVED DIKETONES AS EFFICIENT VISIBLE LIGHT PHOTOINITIATORS | BOWLING GREEN STATE UNIVERSITY (US) | 2023-06-15 | — | — | US | disclosed |
| CN-108101842-B | Preparation method of 2-hydroxy-4-carboxyquinoline | 山东诚汇双达药业有限公司 | 2021-04-30 | — | — | CN | disclosed |
| WO-2007084625-A9 | NOVEL COMPOUNDS AND METHODS FOR INHIBITING P53 ACTIVITY | SINAI SCHOOL MEDICINE (US) | 2007-09-13 | — | — | WO | disclosed |
| WO-2007084625-A2 | NOVEL COMPOUNDS AND METHODS FOR INHIBITING P53 ACTIVITY | MOUNT SINAI SCHOOL OF MEDICINE (US) | 2007-07-26 | — | — | WO | disclosed |
| US-5736534-A | HYPERPROLIFERATIVE DISEASES; INHIBITORS OF PROTEIN-TYROSINE KINASES SUCH AS EPIDERMAL GROWTH FACTOR RECEPTOR; BRAIN, LUNG, BREAST CANCER; PSORIASIS AND BENIGN PROSTATE HYPERPLASIA | PFIZER INC. (US) | 1998-04-07 | — | — | US | disclosed |
| EP-0746554-A1 | 4-HETEROCYCLYL-SUBSTITUTED QUINAZOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS ANTI-CANCER AGENTS | PFIZER INC. (US) | 1996-12-11 | — | — | EP | disclosed |
| WO-1995023141-A1 | 4-HETEROCYCLYL-SUBSTITUTED QUINAZOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS ANTI-CANCER AGENTS | PFIZER INC. (US) | 1995-08-31 | — | — | WO | disclosed |
| EP-0123146-B1 | COMPOUND WITH ANTIINFLAMMATORY ACTIVITY, PROCESS FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS THEREFROM | CHIESI FARMACEUTICI S.p.A. (IT) | 1990-05-23 | — | — | EP | disclosed |
| US-4839366-A | ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC | CHIESI FARMACEUTICI S.P.A. (IT) | 1989-06-13 | — | — | US | disclosed |
| US-4767698-A | PHOTOSTABILITY, HEAT RESISTANCE | AGFA-GEVAERT AKTIENGESELLSCHAFT (DE) | 1988-08-30 | — | — | US | disclosed |
| EP-0123146-A2 | Compound with antiinflammatory activity, process for preparation thereof and pharmaceutical compositions therefrom | CHIESI FARMACEUTICI S.p.A. (IT) | 1984-10-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10065927-B2 | α-ketoacylic isoniazid compounds, process for producing said compounds, use of the compounds in the treatment of tuberculosis | HMGCR, IDH3A, COASY | CES1 411/4885ALDH1A1 512/4885MAPT 2810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.