Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.30 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.30 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.30 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.30 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.30 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.30 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.30 |
| ▸ | CTSL | P07711 | 1/20 | 0.30 |
| ▸ | CTSB | P07858 | 1/20 | 0.30 |
| ▸ | CTSH | P09668 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3338663 | 0.82 | PSEN1 (0.31) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4078795 | 0.82 | PSEN1 (0.31) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL13242430 | 0.80 | HTR2C (0.31) | CTSSCTSLCTSB | |
| SCHEMBL499442 | 0.80 | HTR2C (0.31) | CTSSCTSLCTSB | |
| SCHEMBL8079730 | 0.77 | PSEN1 (0.32) | CTSSPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8065598 | 0.77 | PSEN1 (0.39) | CTSSPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8004071 | 0.77 | PSEN1 (0.32) | CTSSPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7998425 | 0.77 | PSEN1 (0.32) | CTSSPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8077145 | 0.77 | PSEN1 (0.32) | CTSSPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3263902 | 0.77 | PSEN1 (0.32) | CTSSPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106221-B2 | Renin inhibitors | VITAE PHARMACEUTICALS, INC. (US) | 2012-01-31 | — | — | US | disclosed |