Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C3AR1 | Q16581 | 1/20 | 0.39 |
| ▸ | PLG | P00747 | 2/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | TGM2 | P21980 | 2/20 | 0.31 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 7/20 | 0.30 |
| ▸ | ACHE | P22303 | 7/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4994558 | 0.95 | C3AR1 (0.37) | C3AR1PLGF10PLAUKLKB1 | |
| SCHEMBL4996400 | 0.92 | C3AR1 (0.48) | C3AR1PLGF10PLAUKLKB1 | |
| SCHEMBL4433961 | 0.92 | C3AR1 (0.39) | C3AR1PLGF10PLAUKLKB1 | |
| SCHEMBL4990890 | 0.92 | C3AR1 (0.39) | C3AR1PLGF10PLAUKLKB1 | |
| SCHEMBL4997674 | 0.92 | C3AR1 (0.39) | C3AR1PLGF10PLAUKLKB1 | |
| SCHEMBL4439721 | 0.92 | PLG (0.40) | C3AR1PLGF10PLAUKLKB1 | |
| SCHEMBL4994776 | 0.92 | PLG (0.40) | C3AR1PLGF10PLAUKLKB1 | |
| SCHEMBL4995029 | 0.91 | C3AR1 (0.36) | C3AR1PLGF10PLAUKLKB1 | |
| SCHEMBL4430980 | 0.90 | C3AR1 (0.35) | C3AR1PLGF10PLAUKLKB1 | |
| SCHEMBL4429634 | 0.90 | F2 (0.38) | C3AR1PLGF10PLAUKLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968972-A1 | ARYL-ISOXAZOLO-4-YL-OXADIAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2008-09-17 | — | — | EP | claimed |
| WO-2007071598-A1 | ARYL-ISOXAZOLO-4-YL-OXADIAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-28 | — | — | WO | claimed |
| EP-1968972-A1 | ARYL-ISOXAZOLO-4-YL-OXADIAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007071598-A1 | ARYL-ISOXAZOLO-4-YL-OXADIAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-28 | — | — | WO | disclosed |