Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.52 |
| ▸ | PTGES | O14684 | 2/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.51 |
| ▸ | EPHX1 | P07099 | 5/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4985082 | 0.92 | NR1H4 (0.49) | NR1H4PTGESALOX5EPHX1CYP2D6 | |
| Hydrochloric Acid SCHEMBL4985557 | 0.91 | NR1H4 (0.48) | NR1H4PTGESALOX5EPHX1CYP2D6 | |
| SCHEMBL4981786 | 0.87 | HDAC8 (0.43) | NR1H4PTGESALOX5EPHX1CYP2D6 | |
| Hydrochloric Acid SCHEMBL4982644 | 0.86 | HDAC8 (0.43) | NR1H4PTGESALOX5CYP2D6NR1I2 | |
| SCHEMBL4980138 | 0.85 | NR1H4 (0.44) | NR1H4PTGESALOX5EPHX1CYP2D6 | |
| SCHEMBL4981260 | 0.85 | NR4A2 (0.50) | NR1H4PTGESALOX5MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL4985726 | 0.84 | NR1H4 (0.43) | NR1H4PTGESALOX5EPHX1CYP2D6 | |
| Hydrochloric Acid SCHEMBL4985642 | 0.84 | NR4A2 (0.49) | NR1H4PTGESALOX5MEN1KMT2A | |
| SCHEMBL4983016 | 0.84 | NR1H4 (0.39) | NR1H4PTGESALOX5EPHX1CYP2D6 | |
| SCHEMBL28128819 | 0.84 | NPC1 (0.53) | MEN1KMT2ARAB9ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080171756-A1 | N-Substituted Glycine Derivatives: Prolyl Hydroxylase Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2008-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080171756-A1 | N-Substituted Glycine Derivatives: Prolyl Hydroxylase Inhibitors | HIF1AN, EGLN2, EGLN3 | NR1H4 1509/4885PTGES 589/4885ALOX5 1656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.