Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 5/20 | 0.45 |
| ▸ | BCR | P11274 | 5/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | RPS6KA2 | Q15349 | 2/20 | 0.39 |
| ▸ | GPR6 | P46095 | 1/20 | 0.39 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | STS | P08842 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5002670 | 0.94 | EGFR (0.43) | ABL1BCRCDC7EGFRRPS6KA2 | |
| SCHEMBL4996904 | 0.92 | CDC7 (0.46) | CDC7RPS6KA2CYP2C8ALDH1A1KMT2A | |
| SCHEMBL4996999 | 0.91 | CDC7 (0.42) | ABL1BCRCDC7EGFRRPS6KA2 | |
| SCHEMBL4991418 | 0.88 | CDC7 (0.49) | CDC7RPS6KA2GRM5ALDH1A1KMT2A | |
| SCHEMBL4993909 | 0.87 | CDC7 (0.48) | CDC7EGFRCYP2C8ALDH1A1KMT2A | |
| SCHEMBL4999920 | 0.86 | CDC7 (0.44) | CDC7ALDH1A1HPGDKMT2APARP1 | |
| SCHEMBL4995091 | 0.86 | CYP2C8 (0.40) | ABL1BCRCDC7EGFRRPS6KA2 | |
| SCHEMBL4997509 | 0.86 | CDC7 (0.51) | CDC7RPS6KA2CYP2C8ALDH1A1KMT2A | |
| SCHEMBL4991381 | 0.84 | CDC7 (0.42) | CDC7RPS6KA2STSALDH1A1 | |
| SCHEMBL14188466 | 0.83 | CDC7 (0.48) | CDC7EGFRRPS6KA2CYP2C8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080113971-A1 | PYRAZOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS | HANAU CATHLEEN E | 2008-05-15 | — | — | US | disclosed |
| US-20080113971-A1 | PYRAZOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS | HANAU CATHLEEN E | 2008-05-15 | — | — | US | disclosed |
| US-20080113971-A1 | PYRAZOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS | HANAU CATHLEEN E | 2008-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113971-A1 | PYRAZOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS | MKNK2, MAPKAPK2, MAP3K2 | ABL1 563/4885BCR 3771/4885CDC7 487/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.