Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.73 |
| ▸ | MTOR | P42345 | 20/20 | 0.73 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.71 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.71 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL55768 | 0.90 | PIK3CA (0.72) | PIK3CAMTORPIK3CDPIK3CBAURKB | |
| SCHEMBL5000998 | 0.88 | PIK3CA (0.73) | PIK3CAMTOR | |
| SCHEMBL3916231 | 0.86 | PIK3CA (0.88) | PIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL4989691 | 0.86 | PIK3CA (0.56) | PIK3CAMTOR | |
| SCHEMBL3989011 | 0.85 | PIK3CA (0.93) | PIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL55397 | 0.84 | PIK3CA (0.63) | PIK3CAMTOR | |
| SCHEMBL3984934 | 0.84 | PIK3CA (0.84) | PIK3CAMTORPIK3CDPIK3CBAURKB | |
| SCHEMBL5000585 | 0.84 | PIK3CA (1.00) | PIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL3991344 | 0.84 | PIK3CA (0.86) | PIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL3992960 | 0.84 | PIK3CA (0.87) | PIK3CAMTORPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234262-A1 | PYRAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | WYETH (US) | 2008-09-25 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234262-A1 | PYRAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | MTOR, PIK3CA, PDPK1 | PIK3CA 2/4885MTOR 1/4885PIK3CD 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.