⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27311005 | 0.76 | — | — | |
| SCHEMBL27955121 | 0.76 | EPHX1 (0.50) | — | |
| SCHEMBL11501723 | 0.74 | — | — | |
| SCHEMBL13229801 | 0.73 | — | — | |
| SCHEMBL15785933 | 0.73 | — | — | |
| Hydrochloric Acid SCHEMBL22771607 | 0.71 | — | — | |
| Hydrochloric Acid SCHEMBL22771608 | 0.71 | — | — | |
| SCHEMBL360449 | 0.69 | — | — | |
| SCHEMBL11662737 | 0.69 | — | — | |
| SCHEMBL17264859 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108026100-B | Substituted 1, 2-dihydro-3H-pyrrolo [1,2-c ] imidazol-3-one antibacterial agents | 爱杜西亚药品有限公司 | 2020-09-18 | — | — | CN | disclosed |
| US-10441576-B2 | Substituted 1,2-dihydro-3H pyrrolo[1,2-c]imidazol-3 one antibacterials | IDORSIA PHARMACEUTICALS LTD. (CH) | 2019-10-15 | — | — | US | disclosed |
| EP-3334737-B1 | SUBSTITUTED 1,2-DIHYDRO-3H-PYRROLO[1,2-C]IMIDAZOL-3-ONE ANTIBACTERIAL COMPOUNDS | IDORSIA PHARMACEUTICALS LTD (CH) | 2019-10-09 | — | — | EP | disclosed |
| US-20180235938-A1 | SUBSTITUTED 1,2-DIHYDRO-3H PYRROLO[1,2-c]IMIDAZOL-3 ONE ANTIBACTERIALS | IDORSIA PHARMACEUTICALS LTD. (CH) | 2018-08-23 | — | — | US | disclosed |
| EP-3334737-A1 | SUBSTITUTED 1,2-DIHYDRO-3H | Idorsia Pharmaceuticals Ltd (CH) | 2018-06-20 | — | — | EP | disclosed |
| WO-2017025562-A1 | SUBSTITUTED 1,2-DIHYDRO-3H PYRROLO[1,2-c]IMIDAZOL-3 ONE ANTIBACTERIALS | ACTELION PHARMACEUTICALS LTD (CH) | 2017-02-16 | — | — | WO | disclosed |
| US-7470701-B2 | Substituted 2,5-heterocyclic derivatives | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-12-30 | — | — | US | disclosed |
| US-20080255120-A1 | SUBSTITUTED 2,5-HETEROCYCLIC DERIVATIVES | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-10-16 | — | — | US | disclosed |
| US-20050256121-A1 | e.g. 3-(4-fluorophenyl)-N-{5-[2-(methylamino)pyrimidin-4-yl]thien-2-yl}propanamide; PKB/Akt kinase inhibitor; anticarcinogenic agent; carcinoma, cancer metastases, squamous cell carcinoma, esophageal squamous cell carcinoma, oral carcinoma, cutaneous T cell lymphoma, Hodgkin's lymphoma | CHIRON CORPORATION (US) | 2005-11-17 | — | — | US | disclosed |
| CN-1045976-A | The alkylamide derivatives of the teicoplanin of new replacement | LEPETIT SPA (IT) | 1990-10-10 | — | — | CN | disclosed |
| US-4912248-A | A 2-naphthyl containing ester | THE PROCTER & GAMBLE COMPANY (US) | 1990-03-27 | — | — | US | disclosed |