Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 20/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.66 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.56 |
| ▸ | APLNR | P35414 | 1/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.56 |
| ▸ | GLP1R | P43220 | 1/20 | 0.56 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.56 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.56 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4677608 | 0.93 | GNRHR (0.76) | GNRHRCYP3A4ADRB2APLNROPRK1 | |
| SCHEMBL4674541 | 0.90 | GNRHR (0.59) | GNRHRCYP3A4 | |
| SCHEMBL4674688 | 0.88 | GNRHR (0.72) | GNRHRCYP3A4 | |
| SCHEMBL5762494 | 0.87 | GNRHR (0.73) | GNRHRCYP3A4ADRB2APLNROPRK1 | |
| SCHEMBL12767444 | 0.84 | GNRHR (0.85) | GNRHRCYP3A4 | |
| SCHEMBL4674615 | 0.82 | GNRHR (0.56) | GNRHRCYP3A4 | |
| SCHEMBL1378023 | 0.82 | GNRHR (0.71) | GNRHRCYP3A4 | |
| SCHEMBL22716571 | 0.82 | GNRHR (0.75) | GNRHRCYP3A4ADRB2APLNROPRK1 | |
| SCHEMBL22716575 | 0.82 | GNRHR (0.75) | GNRHRCYP3A4ADRB2APLNROPRK1 | |
| SCHEMBL5002181 | 0.81 | GNRHR (0.87) | GNRHRCYP3A4ADRB2APLNROPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7419983-B2 | e.g. 3-[{hydroxycarbonylpropyl-amino}-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4(1H,3H)-dione; sex-hormone related diseases; anticarcinogenic agent; endometriosis, uterine fibroids, polycystic ovarian disease | NEUROCRINE BIOSCIENCES, INC. (US) | 2008-09-02 | — | — | US | claimed |