Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 10/20 | 0.82 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.82 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.82 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.82 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.82 |
| ▸ | NPC1 | O15118 | 1/20 | 0.82 |
| ▸ | GMNN | O75496 | 1/20 | 0.82 |
| ▸ | LMNA | P02545 | 1/20 | 0.82 |
| ▸ | TP53 | P04637 | 1/20 | 0.82 |
| ▸ | MAPT | P10636 | 1/20 | 0.82 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.82 |
| ▸ | HPGD | P15428 | 1/20 | 0.82 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.82 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.82 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.82 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.82 |
| ▸ | RAB9A | P51151 | 1/20 | 0.82 |
| ▸ | BLM | P54132 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL187837 | 0.90 | PDE5A (1.00) | PDE5ACYP2D6CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL29352550 | 0.90 | PDE5A (1.00) | PDE5ACYP2D6CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL5564481 | 0.85 | PDE5A (0.73) | PDE5ACYP2D6CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL3071869 | 0.85 | PDE5A (0.77) | PDE5ACYP2D6CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL10252544 | 0.85 | PDE5A (0.77) | PDE5ACYP2D6CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL5110734 | 0.82 | PDE5A (0.84) | PDE5ACYP2D6CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL5559297 | 0.82 | PDE5A (0.84) | PDE5ACYP2D6CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL5558649 | 0.82 | PDE5A (0.84) | PDE5ACYP2D6CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL24777457 | 0.82 | PDE5A (0.72) | PDE5ACYP2D6CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL4849350 | 0.82 | PDE5A (1.00) | PDE5ACYP2D6CYP1A2CYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080193385-A1 | COMPOSITIONS AND METHODS FOR TREATING NEUROPATHY | MAIBACH TODD | 2008-08-14 | — | — | US | claimed |
| US-20080193385-A1 | COMPOSITIONS AND METHODS FOR TREATING NEUROPATHY | MAIBACH TODD | 2008-08-14 | — | — | US | disclosed |