Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 14/20 | 0.69 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.65 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.59 |
| ▸ | KDR | P35968 | 1/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | RAF1 | P04049 | 1/20 | 0.56 |
| ▸ | YES1 | P07947 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5000778 | 0.95 | MAPK14 (0.73) | BRAFMAPK14KDRRAF1YES1 | |
| SCHEMBL4967307 | 0.89 | KDR (0.74) | BRAFMAPK14AURKBKDRAURKA | |
| SCHEMBL5007709 | 0.89 | MAPK14 (0.69) | BRAFMAPK14AURKBKDRAURKA | |
| SCHEMBL29459596 | 0.88 | BRAF (0.71) | BRAFMAPK14RAF1YES1 | |
| SCHEMBL4746679 | 0.88 | BRAF (0.71) | BRAFMAPK14RAF1YES1 | |
| SCHEMBL4967550 | 0.87 | BRAF (0.67) | BRAFRAF1YES1 | |
| SCHEMBL4749211 | 0.86 | BRAF (0.68) | BRAFRAF1YES1 | |
| SCHEMBL4750092 | 0.85 | BRAF (0.69) | BRAF | |
| SCHEMBL5000826 | 0.84 | BRAF (0.66) | BRAFRAF1YES1 | |
| SCHEMBL4750107 | 0.84 | BRAF (0.66) | BRAFRAF1YES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080306096-A1 | Quinazoline Derivatives, Process for Their Preparation and Their Use as Anti-Cancer Agents | ASTRAZENECA AB (SE) | 2008-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306096-A1 | Quinazoline Derivatives, Process for Their Preparation and Their Use as Anti-Cancer Agents | BRAF, RAF1, NRAS | BRAF 1/4885MAPK14 104/4885AURKB 883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.