Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Rifampin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.99 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.99 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.99 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.99 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.99 |
| ▸ | MEN1 | O00255 | 2/20 | 0.99 |
| ▸ | GAA | P10253 | 2/20 | 0.99 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.99 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.99 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.99 |
| ▸ | ABCC3 | O15438 | 2/20 | 0.99 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.99 |
| ▸ | ABCC2 | Q92887 | 2/20 | 0.99 |
| ▸ | SLCO2B1 | O94956 | 2/20 | 0.99 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.99 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.99 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.99 |
| ▸ | SLCO1A2 | P46721 | 2/20 | 0.99 |
| ▸ | SLCO1B3 | Q9NPD5 | 2/20 | 0.99 |
| ▸ | SLCO1B1 | Q9Y6L6 | 2/20 | 0.99 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rifampin SCHEMBL5005948 | 1.00 | MAPT (0.99) | MAPTNR1I2ABCB11ALDH1A1KDM4E | |
| Rifampin SCHEMBL15472876 | 0.99 | MAPT (1.00) | MAPTNR1I2ABCB11ALDH1A1KDM4E | |
| Rifampin SCHEMBL14252040 | 0.99 | MAPT (1.00) | MAPTNR1I2ABCB11ALDH1A1KDM4E | |
| Rifampin SCHEMBL14922822 | 0.99 | MAPT (1.00) | MAPTNR1I2ABCB11ALDH1A1KDM4E | |
| Rifampin SCHEMBL14029509 | 0.99 | MAPT (1.00) | MAPTNR1I2ABCB11ALDH1A1KDM4E | |
| Rifampin SCHEMBL66289 | 0.99 | MAPT (1.00) | MAPTNR1I2ABCB11ALDH1A1KDM4E | |
| Rifampin SCHEMBL16499164 | 0.99 | MAPT (1.00) | MAPTNR1I2ABCB11ALDH1A1KDM4E | |
| Rifampin SCHEMBL22517710 | 0.99 | MAPT (1.00) | MAPTNR1I2ABCB11ALDH1A1KDM4E | |
| Rifampin SCHEMBL22432205 | 0.99 | MAPT (1.00) | MAPTNR1I2ABCB11ALDH1A1KDM4E | |
| Rifampin SCHEMBL13230041 | 0.99 | MAPT (1.00) | MAPTNR1I2ABCB11ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107213472-A | The medicine of medicine microspheres arterial embolic agent is for dynamic model and detection method | 敖国昆 | 2017-09-29 | — | — | CN | claimed |
| EP-2846788-A1 | USE OF COMPOUNDS FOR THE TREATMENT OF PAIN | Akron Molecules AG (AT) | 2015-03-18 | — | — | EP | claimed |
| WO-2013167743-A1 | USE OF COMPOUNDS FOR THE TREATMENT OF PAIN | AKRON MOLECULES GMBH (AT) | 2013-11-14 | — | — | WO | claimed |
| CN-1259386-A | Isoniazid synergistic compound aerosol and its prepn. method | CONG FANZI (CN) | 2000-07-12 | — | — | CN | claimed |
| CN-1134278-A | Aerosol for preventing and curing pulmonary tuberculosis and its preparing method and synergy method | CONG FANZI (CN) | 1996-10-30 | — | — | CN | claimed |
| CN-1105236-A | Aerosol for preventing transmission and curing of lung tuberculosis and preparing process thereof | CONG FANZI (CN) | 1995-07-19 | — | — | CN | claimed |
| CN-111183142-B | Boric acid derivatives | 默克专利股份公司 | 2023-06-16 | — | — | CN | disclosed |
| CN-116096421-A | Methods for treating remission-type multiple sclerosis | 渤健马萨诸塞州股份有限公司 | 2023-05-09 | — | — | CN | disclosed |
| CN-107735401-B | Substituted dihydropyrrolopyrazole derivatives | 宇部兴产株式会社 | 2021-08-31 | — | — | CN | disclosed |
| CN-112469480-A | Boronic acid derivatives | 默克专利股份公司 | 2021-03-09 | — | — | CN | disclosed |
| CN-107074885-B | Boronic acid derivatives | 默克专利股份公司 | 2020-11-27 | — | — | CN | disclosed |
| CN-107001391-B | Boronic acid derivatives | 默克专利股份公司 | 2020-11-27 | — | — | CN | disclosed |
| CN-107001390-B | Boronic acid derivatives | 默克专利股份公司 | 2020-11-27 | — | — | CN | disclosed |
| CN-102178604-A | Device and method for preparing gel microsphere and gel microsphere in which antitubercular agents can be injected | CHINESE PEOPLE S LIBERATION ARMY HOSPITAL NO 309 | 2011-09-14 | — | — | CN | disclosed |
| US-20080091139-A1 | Methods, devices, and kits for microjet drug delivery | CORIUM PHARMA SOLUTIONS, INC. | 2008-04-17 | — | — | US | disclosed |
| WO-2007149514-A9 | METHODS, DEVICES, AND KITS FOR MICROJET DRUG DELIVERY | CORIUM INT INC (US) | 2008-02-07 | — | — | WO | disclosed |
| WO-2007149514-A2 | METHODS, DEVICES, AND KITS FOR MICROJET DRUG DELIVERY | CORIUM INTERNATIONAL, INC. (US) | 2007-12-27 | — | — | WO | disclosed |
| CN-1259386-A | Isoniazid synergistic compound aerosol and its prepn. method | CONG FANZI (CN) | 2000-07-12 | — | — | CN | disclosed |
| CN-1134278-A | Aerosol for preventing and curing pulmonary tuberculosis and its preparing method and synergy method | CONG FANZI (CN) | 1996-10-30 | — | — | CN | disclosed |
| CN-1105236-A | Aerosol for preventing transmission and curing of lung tuberculosis and preparing process thereof | CONG FANZI (CN) | 1995-07-19 | — | — | CN | disclosed |