Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 20/20 | 0.64 |
| ▸ | CHRM2 | P08172 | 17/20 | 0.64 |
| ▸ | CHRM1 | P11229 | 16/20 | 0.64 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.55 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.55 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.55 |
| ▸ | TACR1 | P25103 | 2/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.55 |
| ▸ | HRH1 | P35367 | 2/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5007158 | 0.91 | CHRM3 (0.53) | CHRM3CHRM2CHRM1 | |
| SCHEMBL2816273 | 0.89 | CHRM3 (0.65) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Bromide SCHEMBL5490833 | 0.88 | CHRM3 (0.65) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL5006104 | 0.88 | CHRM3 (0.56) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL5007005 | 0.87 | CHRM3 (0.66) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL5005974 | 0.85 | CHRM3 (0.44) | CHRM3CHRM2CHRM1 | |
| SCHEMBL5006267 | 0.84 | CHRM3 (0.44) | CHRM3CHRM2CHRM1 | |
| SCHEMBL5007077 | 0.84 | CHRM3 (0.61) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| SCHEMBL5006038 | 0.83 | CHRM3 (0.57) | CHRM3CHRM2CHRM1 | |
| SCHEMBL71845 | 0.79 | CHRM3 (1.00) | CHRM3CHRM2CHRM1CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461336-B1 | 1-ALKYL-1-AZONIABICYCLO (2.2.2) OCTANE CARBAMATE DERIVATIVES AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | CHIESI FARMA SPA (IT) | 2013-05-22 | — | — | EP | disclosed |
| US-7452904-B2 | 1-alkyl-1-azoniabicyclo' 2.2.2 octane carbamate derivatives and their use as muscarinic receptor antagonists | CHIESI FARMACEUTICI S.P.A. (IT) | 2008-11-18 | — | — | US | disclosed |
| US-20050043349-A1 | 1-Alkyl-1-azoniabicyclo' 2.2.!octane carbamate derivatives and their use as muscarinic receptor antagonists | LABORATORIOS S.A.L.V.A.T. (ES) | 2005-02-24 | — | — | US | disclosed |
| EP-1461336-A2 | 1-ALKYL-1-AZONIABICYCLO (2.2.2) OCTANE CARBAMATE DERIVATIVES AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | LABORATORIOS S.A.L.V.A.T., S.A. (ES) | 2004-09-29 | — | — | EP | disclosed |
| WO-2003053966-A2 | 1-ALKYL-1-AZONIABICYCLO [2.2.2] OCTANE CARBAMATE DERIVATIVES AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | LABORATORIOS S.A.L.V.A.T., S.A. (ES) | 2003-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043349-A1 | 1-Alkyl-1-azoniabicyclo' 2.2.!octane carbamate derivatives and their use as muscarinic receptor antagonists | CHRM2, CHRM3, CHRM1 | CHRM3 2/4885CHRM2 1/4885CHRM1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.