Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 1/20 | 0.56 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.54 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.54 |
| ▸ | PPARD | Q03181 | 3/20 | 0.53 |
| ▸ | PPARG | P37231 | 2/20 | 0.53 |
| ▸ | PPARA | Q07869 | 2/20 | 0.53 |
| ▸ | F2 | P00734 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4627361 | 0.87 | PTGDR (0.58) | PTGDR2PTGDRF2MAPTLMNA | |
| SCHEMBL2945278 | 0.85 | MAPT (0.70) | PTGDR2PTGDRF2MAPTLMNA | |
| SCHEMBL2944675 | 0.84 | PTGDR (0.55) | PTGDR2PTGDRF2MAPTLMNA | |
| SCHEMBL5526708 | 0.84 | HMGCR (0.60) | HMGCRPTGDR2PTGDRPPARDPPARG | |
| SCHEMBL5517727 | 0.83 | HMGCR (0.56) | HMGCRPTGDR2PTGDRPPARDPPARG | |
| SCHEMBL23434716 | 0.82 | F2 (0.53) | PTGDR2PTGDRF2MAPTLMNA | |
| SCHEMBL4626978 | 0.82 | MAPT (0.65) | PTGDR2PTGDRF2MAPTLMNA | |
| SCHEMBL5004060 | 0.81 | PTGDR (0.73) | PTGDR2PTGDRMAPTLMNAALDH1A1 | |
| SCHEMBL4627039 | 0.81 | PTGDR2 (0.52) | PTGDR2PTGDRPPARDF2MAPT | |
| 2,4-Dichlorophenoxyacetic Acid, Methyl Ester SCHEMBL5004223 | 0.80 | MAPT (0.70) | PTGDR2PTGDRMAPTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7414063-B2 | Inhibitors of Akt (protein kinase B) | ELI LILLY AND COMPANY (US) | 2008-08-19 | — | — | US | disclosed |
| US-20070043040-A1 | Inhibitors of akt (protein kinase b) | ELI LILLY AND COMPANY | 2007-02-22 | — | — | US | disclosed |
| EP-1611105-A1 | ISOQUINOLINE-5-SULFONIC ACID AMIDES AS INHIBITORS OF AKT (PROTEIN KINASE B) | ELI LILLY AND COMPANY (US) | 2006-01-04 | — | — | EP | disclosed |
| WO-2004094386-A1 | ISOQUINOLINE-5-SULFONIC ACID AMIDES AS INHIBITORS OF AKT (PROTEIN KINASE B) | ELI LILLY AND COMPANY (US) | 2004-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043040-A1 | Inhibitors of akt (protein kinase b) | AKT1, AKT2, BRAF | HMGCR 4247/4885PTGDR2 4128/4885PTGDR 4193/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.