Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 5/20 | 0.65 |
| ▸ | PPARG | P37231 | 4/20 | 0.62 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.56 |
| ▸ | TACR1 | P25103 | 1/20 | 0.56 |
| ▸ | CTSS | P25774 | 5/20 | 0.53 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.49 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.49 |
| ▸ | ACE | P12821 | 1/20 | 0.47 |
| ▸ | PPARD | Q03181 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.46 |
| ▸ | CTSK | P43235 | 4/20 | 0.45 |
| ▸ | KLK7 | P49862 | 1/20 | 0.45 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.44 |
| ▸ | CDC25B | P30305 | 2/20 | 0.44 |
| ▸ | CDC25A | P30304 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5007452 | 1.00 | PPARA (0.65) | PPARAPPARGCACNA1BTACR1CTSS | |
| SCHEMBL5001325 | 0.88 | PPARA (0.61) | PPARAPPARGCACNA1BTACR1CTSS | |
| SCHEMBL1371645 | 0.88 | PPARA (0.61) | PPARAPPARGCACNA1BTACR1CTSS | |
| SCHEMBL1371647 | 0.88 | PPARA (0.61) | PPARAPPARGCACNA1BTACR1CTSS | |
| SCHEMBL5001271 | 0.86 | PPARA (0.67) | PPARAPPARGCTSSACEPPARD | |
| SCHEMBL5001274 | 0.86 | PPARA (0.67) | PPARAPPARGCTSSACEPPARD | |
| SCHEMBL3376442 | 0.85 | TACR1 (0.60) | PPARAPPARGCACNA1BTACR1CTSS | |
| SCHEMBL3376451 | 0.85 | TACR1 (0.60) | PPARAPPARGCACNA1BTACR1CTSS | |
| SCHEMBL31407351 | 0.85 | TACR1 (0.60) | PPARAPPARGCACNA1BTACR1CTSS | |
| SCHEMBL5004857 | 0.85 | PPARA (0.66) | PPARAPPARGCTSSACEPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7396846-B2 | Growth hormone secretagogues | ELI LILLY AND COMPANY (US) | 2008-07-08 | — | — | US | disclosed |
| EP-1497316-B1 | GROWTH HORMONE SECRETAGOGUES | LILLY CO ELI (US) | 2006-07-05 | — | — | EP | disclosed |
| US-20050240001-A1 | 2-(2-Amino-2-methylpropionylamino)-3-(2,6-difluoro-3-methylphenyl)methoxy propionic acid N-[5-(4-chlorophenyl)-3,3-dimethyl-1,1-dioxo-2,3-dihydroisothiazol-4-ylmethyl]-N-ethylamide; endogenous human growth hormone controller; non-peptidyl in nature, more metabolically stable | ELI LILLY AND COMPANY (US) | 2005-10-27 | — | — | US | disclosed |
| EP-1497316-A2 | GROWTH HORMONE SECRETAGOGUES | ELI LILLY AND COMPANY (US) | 2005-01-19 | — | — | EP | disclosed |
| WO-2003087070-A2 | GROWTH HORMONE SECRETAGOGUES | ELI LILLY AND COMPANY (US) | 2003-10-23 | — | — | WO | disclosed |