Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 19/20 | 0.67 |
| ▸ | CDK2AP1 | O14519 | 4/20 | 0.67 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4705891 | 0.82 | CHEK1 (0.73) | CHEK1CDK2AP1 | |
| SCHEMBL4211748 | 0.81 | CHEK1 (0.64) | CHEK1CDK2AP1 | |
| SCHEMBL4215540 | 0.81 | CHEK1 (0.86) | CHEK1CDK2AP1 | |
| SCHEMBL4212001 | 0.80 | CHEK1 (1.00) | CHEK1CDK2AP1 | |
| SCHEMBL4215383 | 0.80 | CHEK1 (0.88) | CHEK1CDK2AP1MAP4K4 | |
| SCHEMBL4212933 | 0.80 | CHEK1 (0.91) | CHEK1CDK2AP1 | |
| SCHEMBL4223504 | 0.80 | CHEK1 (0.88) | CHEK1CDK2AP1MAP4K4 | |
| SCHEMBL4211373 | 0.79 | CHEK1 (0.69) | CHEK1CDK2AP1 | |
| SCHEMBL4706268 | 0.78 | CHEK1 (0.68) | CHEK1CDK2AP1 | |
| SCHEMBL5007467 | 0.78 | CHEK1 (0.50) | CHEK1CDK2AP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423061-B2 | Substitute thiophenes and uses thereof | ASTRAZENECA AB (SE) | 2008-09-09 | — | — | US | disclosed |
| US-20060281666-A1 | Substitute thiophenes and uses therof | ASTRAZENECA AB (SE) | 2006-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060281666-A1 | Substitute thiophenes and uses therof | TYMP, TPMT, MGMT | CHEK1 602/4885CDK2AP1 2225/4885MAP4K4 4690/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.