Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terconazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 19/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | CYP51A1 | Q16850 | 3/20 | 1.00 |
| ▸ | FYN | P06241 | 2/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 2/20 | 1.00 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 2/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 2/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 2/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 2/20 | 1.00 |
| ▸ | HTR2A | P28223 | 2/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 2/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 2/20 | 1.00 |
| ▸ | PGR | P06401 | 1/20 | 1.00 |
| ▸ | CHRM4 | P08173 | 1/20 | 1.00 |
| ▸ | CHRM5 | P08912 | 1/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 1/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terconazole SCHEMBL4924542 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNACYP51A1FYNNR1I2 | |
| Terconazole SCHEMBL17493426 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNACYP51A1FYNNR1I2 | |
| Terconazole SCHEMBL7601910 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNACYP51A1FYNNR1I2 | |
| Terconazole SCHEMBL18258318 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNACYP51A1FYNNR1I2 | |
| Terconazole SCHEMBL23165 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNACYP51A1FYNNR1I2 | |
| Terconazole SCHEMBL29388408 | 1.00 | CYP3A4 (1.00) | CYP3A4LMNACYP51A1FYNNR1I2 | |
| Terconazole SCHEMBL4923831 | 0.99 | CYP3A4 (0.98) | CYP3A4LMNACYP51A1FYNNR1I2 | |
| Terconazole SCHEMBL9043676 | 0.99 | CYP3A4 (0.98) | CYP3A4LMNACYP51A1FYNNR1I2 | |
| Terconazole SCHEMBL1066299 | 0.94 | CYP3A4 (0.89) | CYP3A4LMNACYP51A1FYNNR1I2 | |
| Terconazole SCHEMBL6233263 | 0.94 | CYP3A4 (0.89) | CYP3A4LMNACYP51A1FYNNR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1048288-B1 | Use of halogenated antimycotic- and cationic antibacterial-compounds for the treatment of dandruff | OREAL (FR) | 2007-06-27 | — | — | EP | claimed |
| US-4358449-A | 1-(1,3-Dioxolan-2-ylmethyl)-1H-1,2,4-triazoles and compositions | JANSSEN PHARMACEUTICA, N.V. (BE) | 1982-11-09 | — | — | US | claimed |
| WO-2021151964-A1 | USE OF AZOLE COMPOUNDS TO STIMULATE THE IMMUNE SYSTEM AND AS INHIBITORS FOR S-PLA2GIB | DIACCURATE (FR) | 2021-08-05 | — | — | WO | disclosed |
| EP-3858357-A1 | USE OF AZOLE COMPOUNDS TO STIMULATE THE IMMUNE SYSTEM AND AS INHIBITORS FOR S-PLA2GIB | Diaccurate (FR) | 2021-08-04 | — | — | EP | disclosed |
| EP-2803357-B1 | Angiogenesis inhibitors | UNIV JOHNS HOPKINS (US) | 2020-11-18 | — | — | EP | disclosed |
| US-9642865-B2 | Angiogenesis inhibitors | THE JOHNS HOPKINS UNIVERSITY (US) | 2017-05-09 | — | — | US | disclosed |
| US-8980930-B2 | Angiogenesis inhibitors | THE JOHNS HOPKINS UNIVERSITY (US) | 2015-03-17 | — | — | US | disclosed |
| US-20150056267-A1 | ANGIOGENESIS INHIBITORS | UNIV JOHNS HOPKINS (US) | 2015-02-26 | — | — | US | disclosed |
| EP-2803357-A2 | Angiogenesis inhibitors | THE JOHNS-HOPKINS UNIVERSITY (US) | 2014-11-19 | — | — | EP | disclosed |
| US-20130101657-A1 | ANGIOGENESIS INHIBITORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2013-04-25 | — | — | US | disclosed |
| US-20080193499-A1 | Angiogenesis Inhibitors | THE JOHNS HOPKINS UNIVERSITY (US) | 2008-08-14 | — | — | US | disclosed |
| EP-1765336-A2 | ANGIOGENESIS INHIBITORS | THE JOHNS-HOPKINS UNIVERSITY (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006004795-A2 | ANGIOGENESIS INHIBITORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2006-01-12 | — | — | WO | disclosed |
| EP-1244445-B1 | USE OF AZOLES FOR PREVENTING SKIN CANCER DUE TO RADIATION | BAYER HEALTHCARE AG (DE) | 2005-08-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150056267-A1 | ANGIOGENESIS INHIBITORS | FLT1, VEGFA, FLT4 | CYP3A4 4792/4885LMNA 3841/4885CYP51A1 1225/4885 |
| US-20080193499-A1 | Angiogenesis Inhibitors | FLT1, VEGFA, FLT4 | CYP3A4 4792/4885LMNA 3841/4885CYP51A1 1225/4885 |
| US-20130101657-A1 | ANGIOGENESIS INHIBITORS | FLT1, VEGFA, FLT4 | CYP3A4 4792/4885LMNA 3841/4885CYP51A1 1225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.