Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.49 |
| ▸ | AKT1 | P31749 | 16/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 15/20 | 0.46 |
| ▸ | RPS6KA1 | Q15418 | 14/20 | 0.46 |
| ▸ | AKT2 | P31751 | 6/20 | 0.46 |
| ▸ | RPS6KA5 | O75582 | 6/20 | 0.45 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5009039 | 0.96 | SLC2A1 (0.48) | SLC2A1AKT1ROCK1RPS6KA1AKT2 | |
| SCHEMBL4298401 | 0.91 | SLC2A1 (0.50) | SLC2A1AKT1ROCK1RPS6KA1AKT2 | |
| SCHEMBL5010271 | 0.89 | SLC2A1 (0.51) | SLC2A1AKT1ROCK1RPS6KA1AKT2 | |
| SCHEMBL4292488 | 0.84 | SLC2A1 (0.59) | SLC2A1AKT1ROCK1RPS6KA1AKT2 | |
| SCHEMBL5012630 | 0.80 | SLC2A1 (0.49) | SLC2A1AKT1ROCK1RPS6KA1AKT2 | |
| SCHEMBL4290330 | 0.79 | SLC2A1 (0.58) | SLC2A1AKT1ROCK1RPS6KA1AKT2 | |
| SCHEMBL4298408 | 0.79 | SLC2A1 (0.52) | SLC2A1AKT1ROCK1RPS6KA1AKT2 | |
| SCHEMBL4303916 | 0.79 | AKT1 (0.52) | SLC2A1AKT1ROCK1RPS6KA1AKT2 | |
| SCHEMBL4297083 | 0.78 | SLC2A1 (0.51) | SLC2A1AKT1ROCK1RPS6KA1AKT2 | |
| SCHEMBL13702485 | 0.78 | AKT1 (0.54) | SLC2A1AKT1ROCK1RPS6KA1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948185-A2 | INHIBITORS OF AKT ACTIVITY | SmithKline Beecham Corporation (US) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007058852-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-24 | — | — | WO | disclosed |