Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 2/20 | 0.33 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.33 |
| ▸ | ITGAL | P20701 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4915815 | 0.81 | ITGAL (0.37) | ITGB2ICAM1ITGAL | |
| SCHEMBL4912803 | 0.81 | ITGAL (0.37) | ITGB2ICAM1ITGAL | |
| SCHEMBL3385514 | 0.80 | ITGAL (0.33) | ITGB2ICAM1ITGAL | |
| SCHEMBL4915076 | 0.78 | ITGAL (0.35) | ITGB2ICAM1ITGAL | |
| SCHEMBL4638102 | 0.78 | ITGAL (0.35) | ITGB2ICAM1ITGAL | |
| SCHEMBL4638944 | 0.75 | ITGAL (0.33) | ITGB2ICAM1ITGAL | |
| SCHEMBL4913351 | 0.75 | ITGAL (0.33) | ITGB2ICAM1ITGAL | |
| SCHEMBL4637829 | 0.74 | ITGAL (0.38) | ITGB2ICAM1ITGAL | |
| SCHEMBL4637459 | 0.74 | ITGAL (0.38) | ITGB2ICAM1ITGAL | |
| SCHEMBL14025847 | 0.74 | ITGAL (0.31) | ITGB2ICAM1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1933835-A1 | PHARMACEUTICALLY ACTIVE TETRAHYDRO-PYRROLO[1,2-B]ISOTHIAZOLE 1,1-DIOXIDES | Novartis AG (CH) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007039616-A1 | PHARMACEUTICALLY ACTIVE TETRAHYDRO-PYRROLO[1,2-B]ISOTHIAZOLE 1,1-DIOXIDES | NOVARTIS AG (CH) | 2007-04-12 | — | — | WO | disclosed |